{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Choreziak-Michalak A"],"funding":["Research Grant of Doctoral School, Poznan University of Medical Sciences"],"pagination":["78"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9960447"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["The aim of this study was to investigate the association between selected polymorphisms of nitric oxide synthetase (eNOS) and endothelin-1 (EDN-1) with the occurrence and progression of retinopathy of prematurity (ROP). A prospective study was conducted on 90 preterm infants (44 female), comparing 39 cases with ROP and 51 controls without ROP. Patients who developed ROP were further divided into two subgroups-those with spontaneous regression of the disease and those with ROP requiring treatment. We found that preterm infants with TT genotype eNOS 894G > T had a 12.8-fold higher risk of developing ROP requiring treatment (p = 0.02). Our results showed that allele T of eNOS894G > T polymorphism was significantly more prevalent in ROP patients requiring treatment (p = 0.029). We also investi"],"journal":["BMC ophthalmology"],"pubmed_title":["Potential role of eNOS and EDN-1 gene polymorphisms in the development and progression of retinopathy of prematurity."],"pmcid":["PMC9960447"],"funding_grant_id":["502-14-11121500-45047"],"pubmed_authors":["Szpecht D","Chmielarz-Czarnocinska A","Seremak-Mrozikiewicz A","Gotz-Wieckowska A","Choreziak-Michalak A"],"additional_accession":[]},"is_claimable":false,"name":"Potential role of eNOS and EDN-1 gene polymorphisms in the development and progression of retinopathy of prematurity.","description":"The aim of this study was to investigate the association between selected polymorphisms of nitric oxide synthetase (eNOS) and endothelin-1 (EDN-1) with the occurrence and progression of retinopathy of prematurity (ROP). A prospective study was conducted on 90 preterm infants (44 female), comparing 39 cases with ROP and 51 controls without ROP. Patients who developed ROP were further divided into two subgroups-those with spontaneous regression of the disease and those with ROP requiring treatment. We found that preterm infants with TT genotype eNOS 894G > T had a 12.8-fold higher risk of developing ROP requiring treatment (p = 0.02). Our results showed that allele T of eNOS894G > T polymorphism was significantly more prevalent in ROP patients requiring treatment (p = 0.029). We also investi","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-21T17:24:05.782Z","creation":"2024-12-04T12:37:05.934Z"},"accession":"S-EPMC9960447","cross_references":{"pubmed":["36829141"],"doi":["10.1186/s12886-023-02810-x"]}}