biostudies-literatureChoreziak-Michalak AResearch Grant of Doctoral School, Poznan University of Medical Sciences78https://www.ebi.ac.uk/biostudies/studies/S-EPMC9960447biostudies-literatureUnknown23(1)The aim of this study was to investigate the association between selected polymorphisms of nitric oxide synthetase (eNOS) and endothelin-1 (EDN-1) with the occurrence and progression of retinopathy of prematurity (ROP). A prospective study was conducted on 90 preterm infants (44 female), comparing 39 cases with ROP and 51 controls without ROP. Patients who developed ROP were further divided into two subgroups-those with spontaneous regression of the disease and those with ROP requiring treatment. We found that preterm infants with TT genotype eNOS 894G > T had a 12.8-fold higher risk of developing ROP requiring treatment (p = 0.02). Our results showed that allele T of eNOS894G > T polymorphism was significantly more prevalent in ROP patients requiring treatment (p = 0.029). We also investiBMC ophthalmologyPotential role of eNOS and EDN-1 gene polymorphisms in the development and progression of retinopathy of prematurity.PMC9960447502-14-11121500-45047Szpecht DChmielarz-Czarnocinska ASeremak-Mrozikiewicz AGotz-Wieckowska AChoreziak-Michalak AfalsePotential role of eNOS and EDN-1 gene polymorphisms in the development and progression of retinopathy of prematurity.The aim of this study was to investigate the association between selected polymorphisms of nitric oxide synthetase (eNOS) and endothelin-1 (EDN-1) with the occurrence and progression of retinopathy of prematurity (ROP). A prospective study was conducted on 90 preterm infants (44 female), comparing 39 cases with ROP and 51 controls without ROP. Patients who developed ROP were further divided into two subgroups-those with spontaneous regression of the disease and those with ROP requiring treatment. We found that preterm infants with TT genotype eNOS 894G > T had a 12.8-fold higher risk of developing ROP requiring treatment (p = 0.02). Our results showed that allele T of eNOS894G > T polymorphism was significantly more prevalent in ROP patients requiring treatment (p = 0.029). We also investi2023-01-01T00:00:00Z2023 Feb2025-04-21T17:24:05.782Z2024-12-04T12:37:05.934ZS-EPMC99604473682914110.1186/s12886-023-02810-x