{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu X"],"funding":["the Research Project of Jinan Microecological Biomedicine Shandong Laboratory","“20 Articles of Higher Education” Funding Project Independent Training Innovation Team of Jinan","University of Bergen","the Special Foundation for Taishan Scholars","the Clinical Research Center of Shandong University","National Natural Science Foundation of China","Central Guide Local Science and Technology Development Special Funds Projects","the Department of Science & Technology of Shandong Province"],"pagination":["147"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9960449"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(1)"],"pubmed_abstract":["Background
Valtrate, a natural compound isolated from the root of Valeriana, exhibits antitumor activity in many cancers through different mechanisms. However, its efficacy for the treatment of glioblastoma (GBM), a tumor type with a poor prognosis, has not yet been rigorously investigated.Methods
GBM cell lines were treated with valtrate and CCK-8, colony formation and EdU assays, flow cytometry, and transwell, 3D tumor spheroid invasion and GBM-brain organoid co-culture invasion assays were performed to assess properties of proliferation, viability, apoptosis and invasion/migration. RNA sequencing analysis on valtrate-treated cells was performed to identify putative target genes underlying the antitumor activity of the drug in GBM cells. Western blot analysis, immunofluor"],"journal":["Journal of translational medicine"],"pubmed_title":["Valtrate, an iridoid compound in Valeriana, elicits anti-glioblastoma activity through inhibition of the PDGFRA/MEK/ERK signaling pathway."],"pmcid":["PMC9960449"],"funding_grant_id":["81972351","2020CXGC010903","tshw201502056","JNL-2022042C","ZR2019ZD33","2020SDUCRCB002","tsqn201909173","YDZX2021010","2019GXRC006","JNL-2022003A"],"pubmed_authors":["Liu X","Li X","Chen A","Hu Y","Wen M","Yang N","Zhang X","Xue Z","Huang B","Wang J","Liu G"],"additional_accession":[]},"is_claimable":false,"name":"Valtrate, an iridoid compound in Valeriana, elicits anti-glioblastoma activity through inhibition of the PDGFRA/MEK/ERK signaling pathway.","description":"Background
Valtrate, a natural compound isolated from the root of Valeriana, exhibits antitumor activity in many cancers through different mechanisms. However, its efficacy for the treatment of glioblastoma (GBM), a tumor type with a poor prognosis, has not yet been rigorously investigated.Methods
GBM cell lines were treated with valtrate and CCK-8, colony formation and EdU assays, flow cytometry, and transwell, 3D tumor spheroid invasion and GBM-brain organoid co-culture invasion assays were performed to assess properties of proliferation, viability, apoptosis and invasion/migration. RNA sequencing analysis on valtrate-treated cells was performed to identify putative target genes underlying the antitumor activity of the drug in GBM cells. Western blot analysis, immunofluor","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-05-28T19:01:49.53Z","creation":"2025-02-19T00:13:34.29Z"},"accession":"S-EPMC9960449","cross_references":{"pubmed":["36829235"],"doi":["10.1186/s12967-023-03984-0"]}}