biostudies-literatureCurtis AIrish Research CouncilScience Foundation IrelandSFI Research Infrastructure Call 2012222https://www.ebi.ac.uk/biostudies/studies/S-EPMC9961802biostudies-literatureUnknown9(2)<i>Aspergillus fumigatus</i> is an opportunistic fungal pathogen capable of inducing chronic and acute infection in susceptible patients. <i>A. fumigatus</i> interacts with numerous bacteria that compose the microbiota of the lung, including <i>Pseudomonas aeruginosa</i> and <i>Klebsiella pneumoniae</i>, both of which are common isolates from cystic fibrosis sputum. Exposure of <i>A. fumigatus</i> to <i>K. pneumoniae</i> culture filtrate reduced fungal growth and increased gliotoxin production. Qualitative proteomic analysis of the <i>K. pneumoniae</i> culture filtrate identified proteins associated with metal sequestering, enzymatic degradation and redox activity, which may impact fungal growth and development. Quantitative proteomic analysis of <i>A. fumigatus</i> following exposure to <Journal of fungi (Basel, Switzerland)Exposure of <i>Aspergillus fumigatus</i> to <i>Klebsiella pneumoniae</i> Culture Filtrate Inhibits Growth and Stimulates Gliotoxin Production.PMC9961802GOIPG/2021/86012/RI/2346 (3)Ryan MKavanagh KCurtis AfalseExposure of <i>Aspergillus fumigatus</i> to <i>Klebsiella pneumoniae</i> Culture Filtrate Inhibits Growth and Stimulates Gliotoxin Production.<i>Aspergillus fumigatus</i> is an opportunistic fungal pathogen capable of inducing chronic and acute infection in susceptible patients. <i>A. fumigatus</i> interacts with numerous bacteria that compose the microbiota of the lung, including <i>Pseudomonas aeruginosa</i> and <i>Klebsiella pneumoniae</i>, both of which are common isolates from cystic fibrosis sputum. Exposure of <i>A. fumigatus</i> to <i>K. pneumoniae</i> culture filtrate reduced fungal growth and increased gliotoxin production. Qualitative proteomic analysis of the <i>K. pneumoniae</i> culture filtrate identified proteins associated with metal sequestering, enzymatic degradation and redox activity, which may impact fungal growth and development. Quantitative proteomic analysis of <i>A. fumigatus</i> following exposure to <2023-01-01T00:00:00Z2023 Feb2026-04-08T14:40:36.636Z2025-02-18T23:44:25.116ZS-EPMC99618023683633610.3390/jof9020222