{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Elghobary MEN"],"funding":["Japan Society for the Promotion of Science"],"pagination":["1864"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9962004"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(4)"],"pubmed_abstract":["Auger electrons (AEs) are very low-energy electrons emitted by radionuclides such as I-125 (<sup>125</sup>I). This energy is deposited across a small distance (<0.5 μm), resulting in high linear energy transfer that is potent for causing lethal damage to cancer cells. Thus, AE-emitting radiotherapeutic agents have great potential for cancer treatment. In this study, thermosensitive liposomes (TSLs) encapsulating <sup>125</sup>I-labeled doxorubicin (DOX) derivatives were developed for Auger electron therapy, targeting the DNA of cancer cells. A radioiodinated DOX derivative [<sup>125</sup>I]<b>5</b> highly accumulated in the nuclei of cancer cells and showed potent cytotoxicity against Colon 26 cancer cells by AEs. Subsequently, [<sup>125</sup>I]<b>5</b> was loaded into the TSLs with high e"],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Preparation and Evaluation of Thermosensitive Liposomes Encapsulating I-125-Labeled Doxorubicin Derivatives for Auger Electron Therapy."],"pmcid":["PMC9962004"],"funding_grant_id":["22K07812"],"pubmed_authors":["Mishiro K","Ogawa K","Fuchigami T","Elghobary MEN","Munekane M"],"additional_accession":[]},"is_claimable":false,"name":"Preparation and Evaluation of Thermosensitive Liposomes Encapsulating I-125-Labeled Doxorubicin Derivatives for Auger Electron Therapy.","description":"Auger electrons (AEs) are very low-energy electrons emitted by radionuclides such as I-125 (<sup>125</sup>I). This energy is deposited across a small distance (<0.5 μm), resulting in high linear energy transfer that is potent for causing lethal damage to cancer cells. Thus, AE-emitting radiotherapeutic agents have great potential for cancer treatment. In this study, thermosensitive liposomes (TSLs) encapsulating <sup>125</sup>I-labeled doxorubicin (DOX) derivatives were developed for Auger electron therapy, targeting the DNA of cancer cells. A radioiodinated DOX derivative [<sup>125</sup>I]<b>5</b> highly accumulated in the nuclei of cancer cells and showed potent cytotoxicity against Colon 26 cancer cells by AEs. Subsequently, [<sup>125</sup>I]<b>5</b> was loaded into the TSLs with high e","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-04T08:53:07.172Z","creation":"2025-04-04T08:53:07.172Z"},"accession":"S-EPMC9962004","cross_references":{"pubmed":["36838851"],"doi":["10.3390/molecules28041864"]}}