{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Annang FB"],"funding":["Regional Government of Andalusia","Plan Nacional","Instituto de Salud Carlos III","Scientific and technological infrastructures from the Ministerio de Ciencia e Innovación","Junta de Andalucía"],"pagination":["492"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9962372"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(2)"],"pubmed_abstract":["<i>Memnoniella</i> is a fungal genus from which a wide range of diverse biologically active compounds have been isolated. A <i>Memnoniella dichroa</i> CF-080171 extract was identified to exhibit potent activity against <i>Plasmodium falciparum</i> 3D7 and <i>Trypanosoma cruzi</i> Tulahuen whole parasites in a high-throughput screening (HTS) campaign of microbial extracts from the Fundación MEDINA's collection. Bioassay-guided isolation of the active metabolites from this extract afforded eight new meroterpenoids of varying potencies, namely, memnobotrins C-E (<b>1</b>-<b>3</b>), a glycosylated isobenzofuranone (<b>4</b>), a tricyclic isobenzofuranone (<b>5</b>), a tetracyclic benzopyrane (<b>6</b>), a tetracyclic isobenzofuranone (<b>7</b>), and a pentacyclic isobenzofuranone (<b>8</b>). T"],"journal":["Pharmaceutics"],"pubmed_title":["Antiparasitic Meroterpenoids Isolated from <i>Memnoniella dichroa</i> CF-080171."],"pmcid":["PMC9962372"],"funding_grant_id":["INP-2011-0016-PCT-010000 ACT6","PCT-01000-ACT7, 2011-13","SAF PID2019-109623RB-I00","BIO-199","RD16/0027/0015","PCT-010000-2010-4 (NMR)","SAF2016-79957-R","RD16/0027/0014","RD12/0018/0005","Grants Nos. PCT- 010000-2010-4 (NMR), INP-2011-0016-PCT-010000 ACT6 and PCT-01000-ACT7, 2011-13","RICET: RD16/0027/0014, RD16/0027/0015, and RD12/0018/0005","SAF PID2019-109623RB-I00; SAF2016-79957-R"],"pubmed_authors":["Annang FB","Bosch-Navarrete C","Gonzalez-Menendez V","Martin J","Ruiz-Perez LM","Ramos MC","Reyes F","Mackenzie TA","Genilloud O","Gonzalez-Pacanowska D","Perez-Moreno G","Vicente F"],"additional_accession":[]},"is_claimable":false,"name":"Antiparasitic Meroterpenoids Isolated from <i>Memnoniella dichroa</i> CF-080171.","description":"<i>Memnoniella</i> is a fungal genus from which a wide range of diverse biologically active compounds have been isolated. A <i>Memnoniella dichroa</i> CF-080171 extract was identified to exhibit potent activity against <i>Plasmodium falciparum</i> 3D7 and <i>Trypanosoma cruzi</i> Tulahuen whole parasites in a high-throughput screening (HTS) campaign of microbial extracts from the Fundación MEDINA's collection. Bioassay-guided isolation of the active metabolites from this extract afforded eight new meroterpenoids of varying potencies, namely, memnobotrins C-E (<b>1</b>-<b>3</b>), a glycosylated isobenzofuranone (<b>4</b>), a tricyclic isobenzofuranone (<b>5</b>), a tetracyclic benzopyrane (<b>6</b>), a tetracyclic isobenzofuranone (<b>7</b>), and a pentacyclic isobenzofuranone (<b>8</b>). T","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-04-08T13:16:36.272Z","creation":"2024-10-19T01:03:07.544Z"},"accession":"S-EPMC9962372","cross_references":{"pubmed":["36839814"],"doi":["10.3390/pharmaceutics15020492"]}}