biostudies-literatureAnnang FBRegional Government of AndalusiaPlan NacionalInstituto de Salud Carlos IIIScientific and technological infrastructures from the Ministerio de Ciencia e InnovaciónJunta de Andalucía492https://www.ebi.ac.uk/biostudies/studies/S-EPMC9962372biostudies-literatureUnknown15(2)<i>Memnoniella</i> is a fungal genus from which a wide range of diverse biologically active compounds have been isolated. A <i>Memnoniella dichroa</i> CF-080171 extract was identified to exhibit potent activity against <i>Plasmodium falciparum</i> 3D7 and <i>Trypanosoma cruzi</i> Tulahuen whole parasites in a high-throughput screening (HTS) campaign of microbial extracts from the Fundación MEDINA's collection. Bioassay-guided isolation of the active metabolites from this extract afforded eight new meroterpenoids of varying potencies, namely, memnobotrins C-E (<b>1</b>-<b>3</b>), a glycosylated isobenzofuranone (<b>4</b>), a tricyclic isobenzofuranone (<b>5</b>), a tetracyclic benzopyrane (<b>6</b>), a tetracyclic isobenzofuranone (<b>7</b>), and a pentacyclic isobenzofuranone (<b>8</b>). TPharmaceuticsAntiparasitic Meroterpenoids Isolated from <i>Memnoniella dichroa</i> CF-080171.PMC9962372INP-2011-0016-PCT-010000 ACT6PCT-01000-ACT7, 2011-13SAF PID2019-109623RB-I00BIO-199RD16/0027/0015PCT-010000-2010-4 (NMR)SAF2016-79957-RRD16/0027/0014RD12/0018/0005Grants Nos. PCT- 010000-2010-4 (NMR), INP-2011-0016-PCT-010000 ACT6 and PCT-01000-ACT7, 2011-13RICET: RD16/0027/0014, RD16/0027/0015, and RD12/0018/0005SAF PID2019-109623RB-I00; SAF2016-79957-RAnnang FBBosch-Navarrete CGonzalez-Menendez VMartin JRuiz-Perez LMRamos MCReyes FMackenzie TAGenilloud OGonzalez-Pacanowska DPerez-Moreno GVicente FfalseAntiparasitic Meroterpenoids Isolated from <i>Memnoniella dichroa</i> CF-080171.<i>Memnoniella</i> is a fungal genus from which a wide range of diverse biologically active compounds have been isolated. A <i>Memnoniella dichroa</i> CF-080171 extract was identified to exhibit potent activity against <i>Plasmodium falciparum</i> 3D7 and <i>Trypanosoma cruzi</i> Tulahuen whole parasites in a high-throughput screening (HTS) campaign of microbial extracts from the Fundación MEDINA's collection. Bioassay-guided isolation of the active metabolites from this extract afforded eight new meroterpenoids of varying potencies, namely, memnobotrins C-E (<b>1</b>-<b>3</b>), a glycosylated isobenzofuranone (<b>4</b>), a tricyclic isobenzofuranone (<b>5</b>), a tetracyclic benzopyrane (<b>6</b>), a tetracyclic isobenzofuranone (<b>7</b>), and a pentacyclic isobenzofuranone (<b>8</b>). T2023-01-01T00:00:00Z2023 Feb2026-04-08T13:16:36.272Z2024-10-19T01:03:07.544ZS-EPMC99623723683981410.3390/pharmaceutics15020492