biostudies-literatureTsai CFChung Shan Medical University Hospital3871https://www.ebi.ac.uk/biostudies/studies/S-EPMC9963554biostudies-literatureUnknown24(4)Myocardial ischemia/reperfusion (I/R) injury is marked by rapid increase in inflammation and not only results in myocardial apoptosis but also compromises the myocardial function. <i>Dunaliella salina</i> (<i>D. salina</i>), a halophilic unicellular microalga, has been used as a provitamin A carotenoid supplement and color additive. Several studies have reported that <i>D. salina</i> extract could attenuate lipopolysaccharides-induced inflammatory effects and regulate the virus-induced inflammatory response in macrophages. However, the effects of <i>D. salina</i> on myocardial I/R injury remain unknown. Therefore, we aimed to investigate the cardioprotection of <i>D. salina</i> extract in rats subjected to myocardial I/R injury that was induced by occlusion of the left anterior descending International journal of molecular sciences<i>Dunaliella salina</i> Alga Protects against Myocardial Ischemia/Reperfusion Injury by Attenuating TLR4 Signaling.PMC9963554CSH-2018-C-031CSH-2020-C-026Chou CYChang CSHuang SSLiao JMTsai JWLiu PHWang YHChen KMWang MTsai CFLin HWSu HHChu YCfalse<i>Dunaliella salina</i> Alga Protects against Myocardial Ischemia/Reperfusion Injury by Attenuating TLR4 Signaling.Myocardial ischemia/reperfusion (I/R) injury is marked by rapid increase in inflammation and not only results in myocardial apoptosis but also compromises the myocardial function. <i>Dunaliella salina</i> (<i>D. salina</i>), a halophilic unicellular microalga, has been used as a provitamin A carotenoid supplement and color additive. Several studies have reported that <i>D. salina</i> extract could attenuate lipopolysaccharides-induced inflammatory effects and regulate the virus-induced inflammatory response in macrophages. However, the effects of <i>D. salina</i> on myocardial I/R injury remain unknown. Therefore, we aimed to investigate the cardioprotection of <i>D. salina</i> extract in rats subjected to myocardial I/R injury that was induced by occlusion of the left anterior descending 2023-01-01T00:00:00Z2023 Feb2025-04-25T22:30:27.253Z2025-04-06T09:04:44.179ZS-EPMC99635543683528110.3390/ijms24043871