{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Slighoua M"],"funding":["Princess Nourah bint Abdulrahman University"],"pagination":["260"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9963972"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(2)"],"pubmed_abstract":["Parsley (<i>Petroselinum sativum</i> Hoffm.) is renowned for its ethnomedicinal uses including managing pain, wound, and dermal diseases. We previously highlighted the estrogenic and anti-inflammatory properties of parsley and profiled the phytochemistry of its polyphenolic fraction using HPLC-DAD. To extend our investigation, we here characterized the phytochemical composition of the hydro-ethanolic extract using LC-MS/MS and GC-MS upon silylation, and evaluated the antioxidant, analgesic, antimicrobial, and wound healing activities of its hydro-ethanolic and polyphenolic fraction. The antioxidant property was assessed using FRAP, DPPH, and TAC assays. The antimicrobial activity was tested against four wound infectious microbes (<i>Staphylococcus aureus</i>, <i>Pseudomonas aeruginosa</i> "],"journal":["Metabolites"],"pubmed_title":["LC-MS/MS and GC/MS Profiling of <i>Petroselinum sativum</i> Hoffm. and Its Topical Application on Burn Wound Healing and Related Analgesic Potential in Rats."],"pmcid":["PMC9963972"],"funding_grant_id":["PNURSP2023R141"],"pubmed_authors":["Amrati FE","Slighoua M","Moussaid FZ","Drioiche A","Conte R","Bari A","Mahdi I","Housseini AI","Kamaly OA","Saleh A","Bousta D"],"additional_accession":[]},"is_claimable":false,"name":"LC-MS/MS and GC/MS Profiling of <i>Petroselinum sativum</i> Hoffm. and Its Topical Application on Burn Wound Healing and Related Analgesic Potential in Rats.","description":"Parsley (<i>Petroselinum sativum</i> Hoffm.) is renowned for its ethnomedicinal uses including managing pain, wound, and dermal diseases. We previously highlighted the estrogenic and anti-inflammatory properties of parsley and profiled the phytochemistry of its polyphenolic fraction using HPLC-DAD. To extend our investigation, we here characterized the phytochemical composition of the hydro-ethanolic extract using LC-MS/MS and GC-MS upon silylation, and evaluated the antioxidant, analgesic, antimicrobial, and wound healing activities of its hydro-ethanolic and polyphenolic fraction. The antioxidant property was assessed using FRAP, DPPH, and TAC assays. The antimicrobial activity was tested against four wound infectious microbes (<i>Staphylococcus aureus</i>, <i>Pseudomonas aeruginosa</i> ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-04T08:52:51.081Z","creation":"2025-04-04T08:52:51.081Z"},"accession":"S-EPMC9963972","cross_references":{"pubmed":["36837879"],"doi":["10.3390/metabo13020260"]}}