{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Keuls RA"],"funding":["HHS | National Institutes of Health","NICHD NIH HHS","HHS | NIH | National Institute of Environmental Health Sciences","NCRR NIH HHS","NIEHS NIH HHS","NHLBI NIH HHS","Andrew McDonough B+ Foundation","HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development","NCI NIH HHS","V Foundation for Cancer Research","Cancer Prevention and Research Institute of Texas"],"pagination":["e2212578120"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9963983"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["120(6)"],"pubmed_abstract":["Developmental potential is progressively restricted after germ layer specification during gastrulation. However, cranial neural crest cells challenge this paradigm, as they develop from anterior ectoderm, yet give rise to both ectodermal derivatives of the peripheral nervous system and ectomesenchymal bone and cartilage. How cranial neural crest cells differentiate into multiple lineages is poorly understood. Here, we demonstrate that cranial neural crest cells possess a transient state of increased chromatin accessibility. We profile the spatiotemporal emergence of premigratory neural crest and find evidence of lineage bias toward either a neuronal or ectomesenchymal fate, with each expressing distinct factors from earlier stages of development. We identify the miR-302 miRNA family to be "],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Post-transcriptional regulation in cranial neural crest cells expands developmental potential."],"pmcid":["PMC9963983"],"funding_grant_id":["R01-HD099252 R01-HD098131","Parchem","RR150106","T32 ES027801","#V2017-017","T32 HL092332","S10 RR024574","T32 ES027801-04","R01 HD098131","P30 CA125123","R01 HD099252"],"pubmed_authors":["Parchem RJ","Keuls RA","Oh YS","Patel I"],"additional_accession":[]},"is_claimable":false,"name":"Post-transcriptional regulation in cranial neural crest cells expands developmental potential.","description":"Developmental potential is progressively restricted after germ layer specification during gastrulation. However, cranial neural crest cells challenge this paradigm, as they develop from anterior ectoderm, yet give rise to both ectodermal derivatives of the peripheral nervous system and ectomesenchymal bone and cartilage. How cranial neural crest cells differentiate into multiple lineages is poorly understood. Here, we demonstrate that cranial neural crest cells possess a transient state of increased chromatin accessibility. We profile the spatiotemporal emergence of premigratory neural crest and find evidence of lineage bias toward either a neuronal or ectomesenchymal fate, with each expressing distinct factors from earlier stages of development. We identify the miR-302 miRNA family to be ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-04T18:42:31.248Z","creation":"2025-04-04T18:42:31.248Z"},"accession":"S-EPMC9963983","cross_references":{"pubmed":["36724256"],"doi":["10.1073/pnas.2212578120"]}}