{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shen L"],"funding":["Natural Science Foundation of Shanxi Province"],"pagination":["707"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9964092"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(4)"],"pubmed_abstract":["Acetaminophen (AC) is one of the most popular pharmacologically active substances used as an analgesic and antipyretic drug. Herein, a new type of hollow Fe<sub>3</sub>O<sub>4</sub>-rGO/GCE electrode was prepared for electrochemical detection of AC through a three-step approach involving a solvothermal method for the synthesis of hollow Fe<sub>3</sub>O<sub>4</sub> and the chemical reduction of graphene oxide (GO) for reduced graphene oxide (rGO) and Fe<sub>3</sub>O<sub>4</sub>-rGO nanocomposites modified on the glassy carbon electrode (GCE) surface. The as-prepared Fe<sub>3</sub>O<sub>4</sub>-rGO nanocomposites were characterized using a transmission electron microscope (TEM), X-ray diffraction (XRD), and a magnetic measurement system (SQUID-VSM). The magnetic Fe<sub>3</sub>O<sub>4</sub>-rGO/GCE electrodes were employed for the electrochemical detection of AC using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and square wave voltammetry (SWV) and exhibited an ultra-high selectivity and accuracy, a low detection limit of 0.11 µmol/L with a wider linear range from 5 × 10<sup>-7</sup> to 10<sup>-4</sup> mol/L, and high recovery between 100.52% and 101.43%. The obtained Fe<sub>3</sub>O<sub>4</sub>-rGO-modified GCE displays great practical significance for the detection of AC in drug analysis."],"journal":["Nanomaterials (Basel, Switzerland)"],"pubmed_title":["Facile Synthesis of Hollow Fe<sub>3</sub>O<sub>4</sub>-rGO Nanocomposites for the Electrochemical Detection of Acetaminophen."],"pmcid":["PMC9964092"],"funding_grant_id":["202103021223326","202103021223324","20210302123089","20210302123089, 202103021223324 and 202103021223326"],"pubmed_authors":["Shen L","Wen X","Li J","Dong J","Wen B"],"additional_accession":[]},"is_claimable":false,"name":"Facile Synthesis of Hollow Fe<sub>3</sub>O<sub>4</sub>-rGO Nanocomposites for the Electrochemical Detection of Acetaminophen.","description":"Acetaminophen (AC) is one of the most popular pharmacologically active substances used as an analgesic and antipyretic drug. Herein, a new type of hollow Fe<sub>3</sub>O<sub>4</sub>-rGO/GCE electrode was prepared for electrochemical detection of AC through a three-step approach involving a solvothermal method for the synthesis of hollow Fe<sub>3</sub>O<sub>4</sub> and the chemical reduction of graphene oxide (GO) for reduced graphene oxide (rGO) and Fe<sub>3</sub>O<sub>4</sub>-rGO nanocomposites modified on the glassy carbon electrode (GCE) surface. The as-prepared Fe<sub>3</sub>O<sub>4</sub>-rGO nanocomposites were characterized using a transmission electron microscope (TEM), X-ray diffraction (XRD), and a magnetic measurement system (SQUID-VSM). The magnetic Fe<sub>3</sub>O<sub>4</sub>-rGO/GCE electrodes were employed for the electrochemical detection of AC using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and square wave voltammetry (SWV) and exhibited an ultra-high selectivity and accuracy, a low detection limit of 0.11 µmol/L with a wider linear range from 5 × 10<sup>-7</sup> to 10<sup>-4</sup> mol/L, and high recovery between 100.52% and 101.43%. The obtained Fe<sub>3</sub>O<sub>4</sub>-rGO-modified GCE displays great practical significance for the detection of AC in drug analysis.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-05-18T12:54:40.985Z","creation":"2025-05-18T12:54:40.985Z"},"accession":"S-EPMC9964092","cross_references":{"pubmed":["36839075"],"doi":["10.3390/nano13040707"]}}