biostudies-literatureSterner TRUnited States Air Force Office of Scientific ResearchJPC-5187https://www.ebi.ac.uk/biostudies/studies/S-EPMC9964161biostudies-literatureUnknown11(2)An array physiologically-based pharmacokinetic (PBPK) model represents a streamlined method to simultaneously quantify dosimetry of multiple compounds. To predict internal dosimetry of jet fuel components simultaneously, an array PBPK model was coded to simulate inhalation exposures to one or more selected compounds: toluene, ethylbenzene, xylenes, n-nonane, n-decane, and naphthalene. The model structure accounts for metabolism of compounds in the lung and liver, as well as kinetics of each compound in multiple tissues, including the cochlea and brain regions associated with auditory signaling (brainstem and temporal lobe). The model can accommodate either diffusion-limited or flow-limited kinetics (or a combination), allowing the same structure to be utilized for compounds with different ToxicsComplex Mixtures: Array PBPK Modeling of Jet Fuel Components.PMC996416114RH09CORProject: "Validation and application of an array-based mathematical model for fuels exposure and dosimetry"Covington TRSterner TRMattie DRfalseComplex Mixtures: Array PBPK Modeling of Jet Fuel Components.An array physiologically-based pharmacokinetic (PBPK) model represents a streamlined method to simultaneously quantify dosimetry of multiple compounds. To predict internal dosimetry of jet fuel components simultaneously, an array PBPK model was coded to simulate inhalation exposures to one or more selected compounds: toluene, ethylbenzene, xylenes, n-nonane, n-decane, and naphthalene. The model structure accounts for metabolism of compounds in the lung and liver, as well as kinetics of each compound in multiple tissues, including the cochlea and brain regions associated with auditory signaling (brainstem and temporal lobe). The model can accommodate either diffusion-limited or flow-limited kinetics (or a combination), allowing the same structure to be utilized for compounds with different 2023-01-01T00:00:00Z2023 Feb2025-04-05T13:01:31.793Z2025-04-05T13:01:31.793ZS-EPMC99641613685106110.3390/toxics11020187