{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(2)"],"submitter":["Guinet Y"],"pubmed_abstract":["Designing co-amorphous formulations is now recognized as a relevant strategy for improving the bioavailability of low-molecular-weight drugs. In order to determine the most suitable low-molecular-weight excipients for stabilizing the drug in the amorphous state, screening methods were developed mostly using amino acids as co-formers. The present study focused on the analysis of the thermal stability of co-amorphous blends prepared by cryo-milling indomethacin with several amino acids in order to understand the stabilization mechanism of the drug in the amorphous state. Combining low- and mid-frequency Raman investigations has provided information on the relation between the physical properties of the blends and those of the H-bond network of the amorphous drug. This study revealed the surp"],"journal":["Pharmaceutics"],"pagination":["337"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9964172"],"repository":["biostudies-literature"],"pubmed_title":["Mechanism for Stabilizing an Amorphous Drug Using Amino Acids within Co-Amorphous Blends."],"pmcid":["PMC9964172"],"pubmed_authors":["Paccou L","Guinet Y","Hedoux A"],"additional_accession":[]},"is_claimable":false,"name":"Mechanism for Stabilizing an Amorphous Drug Using Amino Acids within Co-Amorphous Blends.","description":"Designing co-amorphous formulations is now recognized as a relevant strategy for improving the bioavailability of low-molecular-weight drugs. In order to determine the most suitable low-molecular-weight excipients for stabilizing the drug in the amorphous state, screening methods were developed mostly using amino acids as co-formers. The present study focused on the analysis of the thermal stability of co-amorphous blends prepared by cryo-milling indomethacin with several amino acids in order to understand the stabilization mechanism of the drug in the amorphous state. Combining low- and mid-frequency Raman investigations has provided information on the relation between the physical properties of the blends and those of the H-bond network of the amorphous drug. This study revealed the surp","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-04T08:52:39.076Z","creation":"2025-04-04T08:52:39.076Z"},"accession":"S-EPMC9964172","cross_references":{"pubmed":["36839663"],"doi":["10.3390/pharmaceutics15020337"]}}