biostudies-literatureUnknown15(2)Guinet YDesigning co-amorphous formulations is now recognized as a relevant strategy for improving the bioavailability of low-molecular-weight drugs. In order to determine the most suitable low-molecular-weight excipients for stabilizing the drug in the amorphous state, screening methods were developed mostly using amino acids as co-formers. The present study focused on the analysis of the thermal stability of co-amorphous blends prepared by cryo-milling indomethacin with several amino acids in order to understand the stabilization mechanism of the drug in the amorphous state. Combining low- and mid-frequency Raman investigations has provided information on the relation between the physical properties of the blends and those of the H-bond network of the amorphous drug. This study revealed the surpPharmaceutics337https://www.ebi.ac.uk/biostudies/studies/S-EPMC9964172biostudies-literatureMechanism for Stabilizing an Amorphous Drug Using Amino Acids within Co-Amorphous Blends.PMC9964172Paccou LGuinet YHedoux AfalseMechanism for Stabilizing an Amorphous Drug Using Amino Acids within Co-Amorphous Blends.Designing co-amorphous formulations is now recognized as a relevant strategy for improving the bioavailability of low-molecular-weight drugs. In order to determine the most suitable low-molecular-weight excipients for stabilizing the drug in the amorphous state, screening methods were developed mostly using amino acids as co-formers. The present study focused on the analysis of the thermal stability of co-amorphous blends prepared by cryo-milling indomethacin with several amino acids in order to understand the stabilization mechanism of the drug in the amorphous state. Combining low- and mid-frequency Raman investigations has provided information on the relation between the physical properties of the blends and those of the H-bond network of the amorphous drug. This study revealed the surp2023-01-01T00:00:00Z2023 Jan2025-04-04T08:52:39.076Z2025-04-04T08:52:39.076ZS-EPMC99641723683966310.3390/pharmaceutics15020337