{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Monteiro LPG"],"funding":["University of Aveiro","Fundação para a Ciência e Tecnologia"],"pagination":["92"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9964173"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(2)"],"pubmed_abstract":["Marine-origin polysaccharides, in particular cationic and anionic ones, have been widely explored as building blocks in fully natural or hybrid electrostatic-driven Layer-by-Layer (LbL) assemblies for bioapplications. However, the low chemical versatility imparted by neutral polysaccharides has been limiting their assembly into LbL biodevices, despite their wide availability in sources such as the marine environment, easy functionality, and very appealing features for addressing multiple biomedical and biotechnological applications. In this work, we report the chemical functionalization of laminarin (LAM) and pullulan (PUL) marine polysaccharides with peptides bearing either six lysine (K<sub>6</sub>) or aspartic acid (D<sub>6</sub>) amino acids via Cu(I)-catalyzed azide-alkyne cycloadditi"],"journal":["Marine drugs"],"pubmed_title":["Unveiling the Assembly of Neutral Marine Polysaccharides into Electrostatic-Driven Layer-by-Layer Bioassemblies by Chemical Functionalization."],"pmcid":["PMC9964173"],"funding_grant_id":["UIDP/50011/2020","LA/P/0006/2020","PTDC/QUI-OUT/30658/2017, CENTRO-01-0145-FEDER-030658","PTDC/QUIQOR/30771/2017 - POCI-01-0145-FEDER-30771","UIDB/50011/2020"],"pubmed_authors":["Mano JF","Monteiro LPG","Borges J","Rodrigues JMM"],"additional_accession":[]},"is_claimable":false,"name":"Unveiling the Assembly of Neutral Marine Polysaccharides into Electrostatic-Driven Layer-by-Layer Bioassemblies by Chemical Functionalization.","description":"Marine-origin polysaccharides, in particular cationic and anionic ones, have been widely explored as building blocks in fully natural or hybrid electrostatic-driven Layer-by-Layer (LbL) assemblies for bioapplications. However, the low chemical versatility imparted by neutral polysaccharides has been limiting their assembly into LbL biodevices, despite their wide availability in sources such as the marine environment, easy functionality, and very appealing features for addressing multiple biomedical and biotechnological applications. In this work, we report the chemical functionalization of laminarin (LAM) and pullulan (PUL) marine polysaccharides with peptides bearing either six lysine (K<sub>6</sub>) or aspartic acid (D<sub>6</sub>) amino acids via Cu(I)-catalyzed azide-alkyne cycloadditi","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-22T10:03:42.819Z","creation":"2024-11-09T23:53:38.756Z"},"accession":"S-EPMC9964173","cross_references":{"pubmed":["36827133"],"doi":["10.3390/md21020092"]}}