biostudies-literatureWang XStartup Foundation for Doctors of Harbin Normal University1985https://www.ebi.ac.uk/biostudies/studies/S-EPMC9964229biostudies-literatureUnknown28(4)<i>Woodwardia japonica</i> is a kind of great potential edible and medicinal fern. In a previous study, it was found that flavonoid and antioxidant activity of <i>W. japonica</i> from different sites were different. However, the cause of the differences has still been unclear, which has restricted the utilization of <i>W. japonica</i>. In this paper, flavonoid and antioxidant activity of <i>W. japonica</i> from nine different regions were determined with the method of a colorimetric assay with UV-VIS spectrophotometry and HPLC-ESI-TOF-MS, and the effects of climate factors on flavonoids and antioxidant activities were evaluated by mathematical modeling and statistical methods. The results showed: (1) total flavonoid content (TFC) of <i>W. japonica</i> from Wuyi Mountain (Jiangxi) was the hMolecules (Basel, Switzerland)Elucidating Flavonoid and Antioxidant Activity in Edible and Medicinal Herbs <i>Woodwardia japonica</i> (L.f.) Sm. Based on HPLC-ESI-TOF-MS and Artificial Neural Network Model: Response to Climatic Factors.PMC9964229XKB20200Tian LFan YWang QCao JLiu BWang XfalseElucidating Flavonoid and Antioxidant Activity in Edible and Medicinal Herbs <i>Woodwardia japonica</i> (L.f.) Sm. Based on HPLC-ESI-TOF-MS and Artificial Neural Network Model: Response to Climatic Factors.<i>Woodwardia japonica</i> is a kind of great potential edible and medicinal fern. In a previous study, it was found that flavonoid and antioxidant activity of <i>W. japonica</i> from different sites were different. However, the cause of the differences has still been unclear, which has restricted the utilization of <i>W. japonica</i>. In this paper, flavonoid and antioxidant activity of <i>W. japonica</i> from nine different regions were determined with the method of a colorimetric assay with UV-VIS spectrophotometry and HPLC-ESI-TOF-MS, and the effects of climate factors on flavonoids and antioxidant activities were evaluated by mathematical modeling and statistical methods. The results showed: (1) total flavonoid content (TFC) of <i>W. japonica</i> from Wuyi Mountain (Jiangxi) was the h2023-01-01T00:00:00Z2023 Feb2025-04-26T00:05:58.291Z2024-11-06T15:32:04.255ZS-EPMC99642293683897310.3390/molecules28041985