{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Guk DA"],"funding":["Russian Science Foundation"],"pagination":["3340"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9964323"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(4)"],"pubmed_abstract":["The search for new anticancer drugs based on biogenic metals, which have weaker side effects compared to platinum-based drugs, remains an urgent task in medicinal chemistry. Titanocene dichloride, a coordination compound of fully biocompatible titanium, has failed in pre-clinical trials but continues to attract the attention of researchers as a structural framework for the development of new cytotoxic compounds. In this study, a series of titanocene (IV) carboxylate complexes, both new and those known from the literature, was synthesized, and their structures were confirmed by a complex of physicochemical methods and X-ray diffraction analysis (including one previously unknown structure based on perfluorinated benzoic acid). The comprehensive comparison of three approaches for the synthesi"],"journal":["International journal of molecular sciences"],"pubmed_title":["New Titanocene (IV) Dicarboxylates with Potential Cytotoxicity: Synthesis, Structure, Stability and Electrochemistry."],"pmcid":["PMC9964323"],"funding_grant_id":["22-73-00004"],"pubmed_authors":["Gandalipov ER","Gibadullina KR","Burlutskiy RO","Tafeenko VA","Guk DA","Shtil AA","Moiseeva AA","Lyssenko KA","Pavlov KG","Beloglazkina EK"],"additional_accession":[]},"is_claimable":false,"name":"New Titanocene (IV) Dicarboxylates with Potential Cytotoxicity: Synthesis, Structure, Stability and Electrochemistry.","description":"The search for new anticancer drugs based on biogenic metals, which have weaker side effects compared to platinum-based drugs, remains an urgent task in medicinal chemistry. Titanocene dichloride, a coordination compound of fully biocompatible titanium, has failed in pre-clinical trials but continues to attract the attention of researchers as a structural framework for the development of new cytotoxic compounds. In this study, a series of titanocene (IV) carboxylate complexes, both new and those known from the literature, was synthesized, and their structures were confirmed by a complex of physicochemical methods and X-ray diffraction analysis (including one previously unknown structure based on perfluorinated benzoic acid). The comprehensive comparison of three approaches for the synthesi","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-04T08:53:14.987Z","creation":"2025-04-04T08:53:14.987Z"},"accession":"S-EPMC9964323","cross_references":{"pubmed":["36834751"],"doi":["10.3390/ijms24043340"]}}