{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pan H"],"funding":["Ningbo “Science and Technology Innovation 2025” Major Projects","Institute Level Project of HwaMei Hospital","Ningbo \"Science and Technology Innovation 2025\" Major Projects"],"pagination":["187"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9964476"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["59(2)"],"pubmed_abstract":["<i>Background and Objectives</i><b>:</b> A significant role was played by costimulatory molecules in renal cancer. However, the lncRNAs regulating costimulatory molecules have not been fully investigated. <i>Materials and Methods</i><b>:</b> Data from the next-sequence file and clinical data were downloaded from the Cancer Genome Atlas (TCGA) database. All analyses were conducted using the R and GraphPad Prism software. <i>Results:</i> A total of 1736 costimulatory molecule-related lncRNAs were determined under the threshold of |Cor| > 0.5 and <i>p</i>-value < 0.001. Furthermore, a prognosis prediction signature consisting of five lncRNAs: LINC00941, AC016773.1, AL162171.1, HOTAIRM1, and AL109741.1 was established with great prediction ability. By combining risk score and clinical paramete"],"journal":["Medicina (Kaunas, Lithuania)"],"pubmed_title":["LINC00941 Promotes Cell Malignant Behavior and Is One of Five Costimulatory Molecule-Related lncRNAs That Predict Prognosis in Renal Clear Cell Carcinoma."],"pmcid":["PMC9964476"],"funding_grant_id":["2019B10062","2020HMKY40"],"pubmed_authors":["Pan H","Pan J","Jin B","Fu G","Wei W"],"additional_accession":[]},"is_claimable":false,"name":"LINC00941 Promotes Cell Malignant Behavior and Is One of Five Costimulatory Molecule-Related lncRNAs That Predict Prognosis in Renal Clear Cell Carcinoma.","description":"<i>Background and Objectives</i><b>:</b> A significant role was played by costimulatory molecules in renal cancer. However, the lncRNAs regulating costimulatory molecules have not been fully investigated. <i>Materials and Methods</i><b>:</b> Data from the next-sequence file and clinical data were downloaded from the Cancer Genome Atlas (TCGA) database. All analyses were conducted using the R and GraphPad Prism software. <i>Results:</i> A total of 1736 costimulatory molecule-related lncRNAs were determined under the threshold of |Cor| > 0.5 and <i>p</i>-value < 0.001. Furthermore, a prognosis prediction signature consisting of five lncRNAs: LINC00941, AC016773.1, AL162171.1, HOTAIRM1, and AL109741.1 was established with great prediction ability. By combining risk score and clinical paramete","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-05-18T12:53:55.86Z","creation":"2025-04-04T21:43:10.714Z"},"accession":"S-EPMC9964476","cross_references":{"pubmed":["36837389"],"doi":["10.3390/medicina59020187"]}}