biostudies-literaturePan HNingbo “Science and Technology Innovation 2025” Major ProjectsInstitute Level Project of HwaMei HospitalNingbo "Science and Technology Innovation 2025" Major Projects187https://www.ebi.ac.uk/biostudies/studies/S-EPMC9964476biostudies-literatureUnknown59(2)<i>Background and Objectives</i><b>:</b> A significant role was played by costimulatory molecules in renal cancer. However, the lncRNAs regulating costimulatory molecules have not been fully investigated. <i>Materials and Methods</i><b>:</b> Data from the next-sequence file and clinical data were downloaded from the Cancer Genome Atlas (TCGA) database. All analyses were conducted using the R and GraphPad Prism software. <i>Results:</i> A total of 1736 costimulatory molecule-related lncRNAs were determined under the threshold of |Cor| > 0.5 and <i>p</i>-value < 0.001. Furthermore, a prognosis prediction signature consisting of five lncRNAs: LINC00941, AC016773.1, AL162171.1, HOTAIRM1, and AL109741.1 was established with great prediction ability. By combining risk score and clinical parameteMedicina (Kaunas, Lithuania)LINC00941 Promotes Cell Malignant Behavior and Is One of Five Costimulatory Molecule-Related lncRNAs That Predict Prognosis in Renal Clear Cell Carcinoma.PMC99644762019B100622020HMKY40Pan HPan JJin BFu GWei WfalseLINC00941 Promotes Cell Malignant Behavior and Is One of Five Costimulatory Molecule-Related lncRNAs That Predict Prognosis in Renal Clear Cell Carcinoma.<i>Background and Objectives</i><b>:</b> A significant role was played by costimulatory molecules in renal cancer. However, the lncRNAs regulating costimulatory molecules have not been fully investigated. <i>Materials and Methods</i><b>:</b> Data from the next-sequence file and clinical data were downloaded from the Cancer Genome Atlas (TCGA) database. All analyses were conducted using the R and GraphPad Prism software. <i>Results:</i> A total of 1736 costimulatory molecule-related lncRNAs were determined under the threshold of |Cor| > 0.5 and <i>p</i>-value < 0.001. Furthermore, a prognosis prediction signature consisting of five lncRNAs: LINC00941, AC016773.1, AL162171.1, HOTAIRM1, and AL109741.1 was established with great prediction ability. By combining risk score and clinical paramete2023-01-01T00:00:00Z2023 Jan2025-05-18T12:53:55.86Z2025-04-04T21:43:10.714ZS-EPMC99644763683738910.3390/medicina59020187