biostudies-literatureWebster JPork CRC297https://www.ebi.ac.uk/biostudies/studies/S-EPMC9964597biostudies-literatureUnknown11(2)<i>Erysipelothrix rhusiopathiae</i> is a bacterial pathogen that is the causative agent of erysipelas in a variety of animals, including swine, emus, turkeys, muskox, caribou, moose, and humans. This study aims to investigate the population structure and genomic features of Australian isolates of <i>E. rhusiopathiae</i> in the Australian pig industry and compare them to the broader scope of isolates worldwide. A total of 178 isolates (154 Australian, seven vaccine isolates, six international isolates, and 11 of unknown origin) in this study were screened against an MLST scheme and publicly available reference isolates, identifying 59 new alleles, with isolates separating into two main single locus variant groups. Investigation with BLASTn revealed the presence of the <i>spaA</i> gene in 17MicroorganismsPopulation Structure and Genomic Characteristics of Australian <i>Erysipelothrix rhusiopathiae</i> Reveals Unobserved Diversity in the Australian Pig Industry.PMC99645972A-117Bogema DWebster JStroud LSales NBowring BMarsh IfalsePopulation Structure and Genomic Characteristics of Australian <i>Erysipelothrix rhusiopathiae</i> Reveals Unobserved Diversity in the Australian Pig Industry.<i>Erysipelothrix rhusiopathiae</i> is a bacterial pathogen that is the causative agent of erysipelas in a variety of animals, including swine, emus, turkeys, muskox, caribou, moose, and humans. This study aims to investigate the population structure and genomic features of Australian isolates of <i>E. rhusiopathiae</i> in the Australian pig industry and compare them to the broader scope of isolates worldwide. A total of 178 isolates (154 Australian, seven vaccine isolates, six international isolates, and 11 of unknown origin) in this study were screened against an MLST scheme and publicly available reference isolates, identifying 59 new alleles, with isolates separating into two main single locus variant groups. Investigation with BLASTn revealed the presence of the <i>spaA</i> gene in 172023-01-01T00:00:00Z2023 Jan2025-04-04T21:43:43.184Z2025-04-04T21:43:43.184ZS-EPMC99645973683826110.3390/microorganisms11020297