biostudies-literatureZhu GChinese University Student Innovation ProjectNational Natural Science Foundation of ChinaShandong provincial Natural Science Foundation162https://www.ebi.ac.uk/biostudies/studies/S-EPMC9964685biostudies-literatureUnknown14(2)<i>Mucor hiemalis</i> BO-1 is an entomopathogenic fungus that infects <i>Bradysia odoriphaga</i>, a destructive root maggot. <i>M. hiemalis</i> BO-1 possesses stronger pathogenicity to the larvae than to other stages of <i>B. odoriphaga</i>, and provides satisfactory field control. However, the physiological response of <i>B. odoriphaga</i> larvae to infection and the infection mechanism of <i>M. hiemalis</i> are unknown. We detected some physiological indicators of diseased <i>B. odoriphaga</i> larvae infected by <i>M. hiemalis</i> BO-1. These included changes in consumption, nutrient contents, and digestive and antioxidant enzymes. We performed transcriptome analysis of diseased <i>B. odoriphaga</i> larvae, and found that <i>M. hiemalis</i> BO-1 showed acute toxicity to <i>B. odoriphaga<InsectsEffects of the Entomopathogenic Fungus <i>Mucor hiemalis</i> BO-1 on the Physical Functions and Transcriptional Signatures of <i>Bradysia odoriphaga</i> Larvae.PMC9964685ZR20191113052832001929S202110447001Ding WChu PJiang LZhu GXue MZhao HfalseEffects of the Entomopathogenic Fungus <i>Mucor hiemalis</i> BO-1 on the Physical Functions and Transcriptional Signatures of <i>Bradysia odoriphaga</i> Larvae.<i>Mucor hiemalis</i> BO-1 is an entomopathogenic fungus that infects <i>Bradysia odoriphaga</i>, a destructive root maggot. <i>M. hiemalis</i> BO-1 possesses stronger pathogenicity to the larvae than to other stages of <i>B. odoriphaga</i>, and provides satisfactory field control. However, the physiological response of <i>B. odoriphaga</i> larvae to infection and the infection mechanism of <i>M. hiemalis</i> are unknown. We detected some physiological indicators of diseased <i>B. odoriphaga</i> larvae infected by <i>M. hiemalis</i> BO-1. These included changes in consumption, nutrient contents, and digestive and antioxidant enzymes. We performed transcriptome analysis of diseased <i>B. odoriphaga</i> larvae, and found that <i>M. hiemalis</i> BO-1 showed acute toxicity to <i>B. odoriphaga<2023-01-01T00:00:00Z2023 Feb2026-04-08T14:36:21.498Z2025-02-18T23:44:22.287ZS-EPMC99646853683573110.3390/insects14020162