{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Abdallah BM"],"funding":["Deputyship for Research & Innovation, Ministry Of Education in Saudi Arabia"],"pagination":["1536"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9965404"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(4)"],"pubmed_abstract":["<i>Trichophyton rubrum</i> is the most common dermatophyte, and can cause cutaneous infections in humans and animals (dermatophytosis). In this study, we investigated the anti-dermatophytic potential of green synthesized silver nanoparticles using <i>Achillea santolina</i> extract (AS-AgNPs) in an in vitro and in vivo rat model of dermal <i>T. rubrum</i> dermatophytosis (TRD). The green synthesis of AS-AgNPs was performed using <i>A. santolina</i> extract and characterized by UV-VIS spectroscopy, zeta potential, imaging (transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and Energy dispersive X-ray analysis (EDX). The antifungal activity of AS-AgNPs was determined by the broth microdilution method, conidial germination, and hypha"],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Potential Treatment of Dermatophyte <i>Trichophyton rubrum</i> in Rat Model Using Topical Green Biosynthesized Silver Nanoparticles with <i>Achillea santolina</i> Extract."],"pmcid":["PMC9965404"],"funding_grant_id":["INST175"],"pubmed_authors":["Rajendran P","Ali EM","Abdallah BM"],"additional_accession":[]},"is_claimable":false,"name":"Potential Treatment of Dermatophyte <i>Trichophyton rubrum</i> in Rat Model Using Topical Green Biosynthesized Silver Nanoparticles with <i>Achillea santolina</i> Extract.","description":"<i>Trichophyton rubrum</i> is the most common dermatophyte, and can cause cutaneous infections in humans and animals (dermatophytosis). In this study, we investigated the anti-dermatophytic potential of green synthesized silver nanoparticles using <i>Achillea santolina</i> extract (AS-AgNPs) in an in vitro and in vivo rat model of dermal <i>T. rubrum</i> dermatophytosis (TRD). The green synthesis of AS-AgNPs was performed using <i>A. santolina</i> extract and characterized by UV-VIS spectroscopy, zeta potential, imaging (transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and Energy dispersive X-ray analysis (EDX). The antifungal activity of AS-AgNPs was determined by the broth microdilution method, conidial germination, and hypha","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-26T00:05:52.413Z","creation":"2025-04-06T09:35:04.538Z"},"accession":"S-EPMC9965404","cross_references":{"pubmed":["36838531"],"doi":["10.3390/molecules28041536"]}}