{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Du Z"],"funding":["Zhao YH","National Key R&amp;D Program of China","Natural Science Foundation of China","345 Talent Project of Shengjing Hospital of China Medical University","Wu QJ","Clinical Research Cultivation Project of Shengjing Hospital","Gong TT","Gao S","JieBangGuaShuai Project of Liaoning Province"],"pagination":["931"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9965699"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(4)"],"pubmed_abstract":["<h4>Background</h4>Current biological evidence suggests that purine involvement in purine metabolism may contribute to the development and progression of ovarian cancer (OC), but the epidemiological association is currently unknown.<h4>Methods</h4>A total of 703 newly diagnosed patients with OC aged 18-79 years were included in this prospective cohort study. Utilizing a verified food-frequency questionnaire, the participants' dietary consumption was gathered. Using medical records and ongoing follow-up, the deaths up until 31 March 2021 were determined. To assess the hazard ratios (HRs) and 95% confidence intervals (CIs) of purine intake with OC mortality, Cox proportional-hazard models were utilized.<h4>Results</h4>During the median follow-up of 31 months (interquartile: 20-47 months), 130 deaths occurred. We observed an improved survival for the highest tercile of total purine intake compared with the lowest tercile (HR = 0.39, 95% CI = 0.19-0.80; <i>p</i> trend < 0.05), and this protective association was mainly attributed to xanthine intake (HR = 0.52, 95% CI = 0.29-0.94, <i>p</i> trend < 0.05). Additionally, we observed a curving relationship in which OC mortality decreased with total purine intake, and the magnitude of the decrease was negatively correlated with intake (<i>p</i> non-linear < 0.05). Significant inverse associations were also observed in subgroup analyses and sensitivity analyses according to demographic and clinical characteristics. Moreover, we observed that xanthine intake and hypoxanthine intake had a multiplicative interaction with ER and PR expression (<i>p</i> < 0.05), respectively.<h4>Conclusion</h4>A high total purine and xanthine intake was linked to a lower risk of OC mortality. Further clarification of these findings is warranted."],"journal":["Nutrients"],"pubmed_title":["Purine Intake and All-Cause Mortality in Ovarian Cancer: Results from a Prospective Cohort Study."],"pmcid":["PMC9965699"],"funding_grant_id":["82103914","No. 2021JH1/1040050","345 Talent Project of Shengjing Hospital of China Medical University","Clinical Research Cultivation Project of Shengjing hospital","No.82103914","2022YFC2704200","No. 2022YFC2704200","2021JH1/1040050"],"pubmed_authors":["Gong T","Wu Q","Qin X","Zou B","Yan S","Du Z","Wei Y","Zhao Y","Xiao Q","Zheng G","Zhao J","Liu F","Gao S"],"additional_accession":[]},"is_claimable":false,"name":"Purine Intake and All-Cause Mortality in Ovarian Cancer: Results from a Prospective Cohort Study.","description":"<h4>Background</h4>Current biological evidence suggests that purine involvement in purine metabolism may contribute to the development and progression of ovarian cancer (OC), but the epidemiological association is currently unknown.<h4>Methods</h4>A total of 703 newly diagnosed patients with OC aged 18-79 years were included in this prospective cohort study. Utilizing a verified food-frequency questionnaire, the participants' dietary consumption was gathered. Using medical records and ongoing follow-up, the deaths up until 31 March 2021 were determined. To assess the hazard ratios (HRs) and 95% confidence intervals (CIs) of purine intake with OC mortality, Cox proportional-hazard models were utilized.<h4>Results</h4>During the median follow-up of 31 months (interquartile: 20-47 months), 130 deaths occurred. We observed an improved survival for the highest tercile of total purine intake compared with the lowest tercile (HR = 0.39, 95% CI = 0.19-0.80; <i>p</i> trend < 0.05), and this protective association was mainly attributed to xanthine intake (HR = 0.52, 95% CI = 0.29-0.94, <i>p</i> trend < 0.05). Additionally, we observed a curving relationship in which OC mortality decreased with total purine intake, and the magnitude of the decrease was negatively correlated with intake (<i>p</i> non-linear < 0.05). Significant inverse associations were also observed in subgroup analyses and sensitivity analyses according to demographic and clinical characteristics. Moreover, we observed that xanthine intake and hypoxanthine intake had a multiplicative interaction with ER and PR expression (<i>p</i> < 0.05), respectively.<h4>Conclusion</h4>A high total purine and xanthine intake was linked to a lower risk of OC mortality. Further clarification of these findings is warranted.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-05-18T12:55:02.251Z","creation":"2025-04-03T22:08:13.355Z"},"accession":"S-EPMC9965699","cross_references":{"pubmed":["36839289"],"doi":["10.3390/nu15040931"]}}