biostudies-literatureDu ZZhao YHNational Key R&amp;D Program of ChinaNatural Science Foundation of China345 Talent Project of Shengjing Hospital of China Medical UniversityWu QJClinical Research Cultivation Project of Shengjing HospitalGong TTGao SJieBangGuaShuai Project of Liaoning Province931https://www.ebi.ac.uk/biostudies/studies/S-EPMC9965699biostudies-literatureUnknown15(4)<h4>Background</h4>Current biological evidence suggests that purine involvement in purine metabolism may contribute to the development and progression of ovarian cancer (OC), but the epidemiological association is currently unknown.<h4>Methods</h4>A total of 703 newly diagnosed patients with OC aged 18-79 years were included in this prospective cohort study. Utilizing a verified food-frequency questionnaire, the participants' dietary consumption was gathered. Using medical records and ongoing follow-up, the deaths up until 31 March 2021 were determined. To assess the hazard ratios (HRs) and 95% confidence intervals (CIs) of purine intake with OC mortality, Cox proportional-hazard models were utilized.<h4>Results</h4>During the median follow-up of 31 months (interquartile: 20-47 months), 130 deaths occurred. We observed an improved survival for the highest tercile of total purine intake compared with the lowest tercile (HR = 0.39, 95% CI = 0.19-0.80; <i>p</i> trend < 0.05), and this protective association was mainly attributed to xanthine intake (HR = 0.52, 95% CI = 0.29-0.94, <i>p</i> trend < 0.05). Additionally, we observed a curving relationship in which OC mortality decreased with total purine intake, and the magnitude of the decrease was negatively correlated with intake (<i>p</i> non-linear < 0.05). Significant inverse associations were also observed in subgroup analyses and sensitivity analyses according to demographic and clinical characteristics. Moreover, we observed that xanthine intake and hypoxanthine intake had a multiplicative interaction with ER and PR expression (<i>p</i> < 0.05), respectively.<h4>Conclusion</h4>A high total purine and xanthine intake was linked to a lower risk of OC mortality. Further clarification of these findings is warranted.NutrientsPurine Intake and All-Cause Mortality in Ovarian Cancer: Results from a Prospective Cohort Study.PMC996569982103914No. 2021JH1/1040050345 Talent Project of Shengjing Hospital of China Medical UniversityClinical Research Cultivation Project of Shengjing hospitalNo.821039142022YFC2704200No. 2022YFC27042002021JH1/1040050Gong TWu QQin XZou BYan SDu ZWei YZhao YXiao QZheng GZhao JLiu FGao SfalsePurine Intake and All-Cause Mortality in Ovarian Cancer: Results from a Prospective Cohort Study.<h4>Background</h4>Current biological evidence suggests that purine involvement in purine metabolism may contribute to the development and progression of ovarian cancer (OC), but the epidemiological association is currently unknown.<h4>Methods</h4>A total of 703 newly diagnosed patients with OC aged 18-79 years were included in this prospective cohort study. Utilizing a verified food-frequency questionnaire, the participants' dietary consumption was gathered. Using medical records and ongoing follow-up, the deaths up until 31 March 2021 were determined. To assess the hazard ratios (HRs) and 95% confidence intervals (CIs) of purine intake with OC mortality, Cox proportional-hazard models were utilized.<h4>Results</h4>During the median follow-up of 31 months (interquartile: 20-47 months), 130 deaths occurred. We observed an improved survival for the highest tercile of total purine intake compared with the lowest tercile (HR = 0.39, 95% CI = 0.19-0.80; <i>p</i> trend < 0.05), and this protective association was mainly attributed to xanthine intake (HR = 0.52, 95% CI = 0.29-0.94, <i>p</i> trend < 0.05). Additionally, we observed a curving relationship in which OC mortality decreased with total purine intake, and the magnitude of the decrease was negatively correlated with intake (<i>p</i> non-linear < 0.05). Significant inverse associations were also observed in subgroup analyses and sensitivity analyses according to demographic and clinical characteristics. Moreover, we observed that xanthine intake and hypoxanthine intake had a multiplicative interaction with ER and PR expression (<i>p</i> < 0.05), respectively.<h4>Conclusion</h4>A high total purine and xanthine intake was linked to a lower risk of OC mortality. Further clarification of these findings is warranted.2023-01-01T00:00:00Z2023 Feb2025-05-18T12:55:02.251Z2025-04-03T22:08:13.355ZS-EPMC99656993683928910.3390/nu15040931