{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(2)"],"submitter":["Wang X"],"pubmed_abstract":["The ongoing COVID-19 pandemic has caused over six million deaths and huge economic burdens worldwide. Antivirals against its causative agent, SARS-CoV-2, are in urgent demand. Previously, we reported that heterocylic compounds, i.e., chloroquine (CQ) and hydroxychloroquine (HCQ), are potent in inhibiting SARS-CoV-2 replication <i>in vitro</i>. In this study, we discussed the syntheses of two novel heterocylic compounds: <i>tert</i>-butyl <i>rel</i>-4-(((3<i>R</i>,4<i>S</i>)-3-(1<i>H</i>-indol-3-yl)-1-oxo-2-propyl-1,2,3,4-tetrahydroisoquinolin-4-yl)methyl)piperazine-1-carboxylate (<i>trans</i>-<b>1</b>) and <i>rel</i>-(3<i>R</i>,4<i>S</i>)-3-(1<i>H</i>-indol-3-yl)-4-(piperazin-1-ylmethyl)-2-propyl-3,4-dihydroisoquinolin-1(2<i>H</i>)-one (<i>trans</i>-<b>2</b>), which effectively suppressed "],"journal":["Viruses"],"pagination":["502"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9965753"],"repository":["biostudies-literature"],"pubmed_title":["Novel Tetrahydroisoquinoline-Based Heterocyclic Compounds Efficiently Inhibit SARS-CoV-2 Infection <i>In Vitro</i>."],"pmcid":["PMC9965753"],"pubmed_authors":["Wang M","Li Y","Li J","Burdzhiev NT","Lozanova VV","Hu H","Kandinska MI","Wang X"],"additional_accession":[]},"is_claimable":false,"name":"Novel Tetrahydroisoquinoline-Based Heterocyclic Compounds Efficiently Inhibit SARS-CoV-2 Infection <i>In Vitro</i>.","description":"The ongoing COVID-19 pandemic has caused over six million deaths and huge economic burdens worldwide. Antivirals against its causative agent, SARS-CoV-2, are in urgent demand. Previously, we reported that heterocylic compounds, i.e., chloroquine (CQ) and hydroxychloroquine (HCQ), are potent in inhibiting SARS-CoV-2 replication <i>in vitro</i>. In this study, we discussed the syntheses of two novel heterocylic compounds: <i>tert</i>-butyl <i>rel</i>-4-(((3<i>R</i>,4<i>S</i>)-3-(1<i>H</i>-indol-3-yl)-1-oxo-2-propyl-1,2,3,4-tetrahydroisoquinolin-4-yl)methyl)piperazine-1-carboxylate (<i>trans</i>-<b>1</b>) and <i>rel</i>-(3<i>R</i>,4<i>S</i>)-3-(1<i>H</i>-indol-3-yl)-4-(piperazin-1-ylmethyl)-2-propyl-3,4-dihydroisoquinolin-1(2<i>H</i>)-one (<i>trans</i>-<b>2</b>), which effectively suppressed ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-22T20:58:42.366Z","creation":"2025-04-06T03:25:15.017Z"},"accession":"S-EPMC9965753","cross_references":{"pubmed":["36851716"],"doi":["10.3390/v15020502"]}}