{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Djoumessi AK"],"funding":["German Academic Exchange Service","Alango Foundation"],"pagination":["298"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9966138"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(2)"],"pubmed_abstract":["The chemical investigation of the EtOH extract from the stem bark of <i>Trichilia monadelpha</i> (Thonn.) J. J. De Wilde afforded two new limonoids (<b>1</b> and <b>2</b>): 24-acetoxy-21,25-dihydroxy-21,23-epoxytirucall-7-en-3-one (<b>1</b>) and (6<i>R</i>)-1-<i>O</i>-deacetylkhayanolide E (<b>2</b>), together with eleven known compounds (<b>3</b>-<b>13</b>), including additional limonoids, flavonoids, triterpenoids, steroids, and fatty acid. Their structures were determined using 1D- and 2D-NMR experiments, ESI mass spectrometry, and single crystal X-ray diffraction analysis. The antibacterial and antiplasmodial activities of the extracts, sub-extracts, fractions, and some of the isolated compounds were evaluated in known pathogenic strains, including <i>Staphylococcus aureus</i> and <i>P"],"journal":["Metabolites"],"pubmed_title":["Constituents of the Stem Bark of <i>Trichilia monadelpha</i> (Thonn.) J. J. De Wilde (Meliaceae) and Their Antibacterial and Antiplasmodial Activities."],"pmcid":["PMC9966138"],"funding_grant_id":["57316173","Reference Hospital of African Medicine"],"pubmed_authors":["Neumann B","Chouna JR","Ayong L","Sewald N","Efange NM","Stammler HG","Bitchagno GTM","Lenta BN","Nkenfou CN","Nkeng-Efouet-Alango P","Nono RN","Djoumessi AK"],"additional_accession":[]},"is_claimable":false,"name":"Constituents of the Stem Bark of <i>Trichilia monadelpha</i> (Thonn.) J. J. De Wilde (Meliaceae) and Their Antibacterial and Antiplasmodial Activities.","description":"The chemical investigation of the EtOH extract from the stem bark of <i>Trichilia monadelpha</i> (Thonn.) J. J. De Wilde afforded two new limonoids (<b>1</b> and <b>2</b>): 24-acetoxy-21,25-dihydroxy-21,23-epoxytirucall-7-en-3-one (<b>1</b>) and (6<i>R</i>)-1-<i>O</i>-deacetylkhayanolide E (<b>2</b>), together with eleven known compounds (<b>3</b>-<b>13</b>), including additional limonoids, flavonoids, triterpenoids, steroids, and fatty acid. Their structures were determined using 1D- and 2D-NMR experiments, ESI mass spectrometry, and single crystal X-ray diffraction analysis. The antibacterial and antiplasmodial activities of the extracts, sub-extracts, fractions, and some of the isolated compounds were evaluated in known pathogenic strains, including <i>Staphylococcus aureus</i> and <i>P","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-26T00:05:04.272Z","creation":"2025-02-18T23:57:44.861Z"},"accession":"S-EPMC9966138","cross_references":{"pubmed":["36837917"],"doi":["10.3390/metabo13020298"]}}