biostudies-literatureDjoumessi AKGerman Academic Exchange ServiceAlango Foundation298https://www.ebi.ac.uk/biostudies/studies/S-EPMC9966138biostudies-literatureUnknown13(2)The chemical investigation of the EtOH extract from the stem bark of <i>Trichilia monadelpha</i> (Thonn.) J. J. De Wilde afforded two new limonoids (<b>1</b> and <b>2</b>): 24-acetoxy-21,25-dihydroxy-21,23-epoxytirucall-7-en-3-one (<b>1</b>) and (6<i>R</i>)-1-<i>O</i>-deacetylkhayanolide E (<b>2</b>), together with eleven known compounds (<b>3</b>-<b>13</b>), including additional limonoids, flavonoids, triterpenoids, steroids, and fatty acid. Their structures were determined using 1D- and 2D-NMR experiments, ESI mass spectrometry, and single crystal X-ray diffraction analysis. The antibacterial and antiplasmodial activities of the extracts, sub-extracts, fractions, and some of the isolated compounds were evaluated in known pathogenic strains, including <i>Staphylococcus aureus</i> and <i>PMetabolitesConstituents of the Stem Bark of <i>Trichilia monadelpha</i> (Thonn.) J. J. De Wilde (Meliaceae) and Their Antibacterial and Antiplasmodial Activities.PMC996613857316173Reference Hospital of African MedicineNeumann BChouna JRAyong LSewald NEfange NMStammler HGBitchagno GTMLenta BNNkenfou CNNkeng-Efouet-Alango PNono RNDjoumessi AKfalseConstituents of the Stem Bark of <i>Trichilia monadelpha</i> (Thonn.) J. J. De Wilde (Meliaceae) and Their Antibacterial and Antiplasmodial Activities.The chemical investigation of the EtOH extract from the stem bark of <i>Trichilia monadelpha</i> (Thonn.) J. J. De Wilde afforded two new limonoids (<b>1</b> and <b>2</b>): 24-acetoxy-21,25-dihydroxy-21,23-epoxytirucall-7-en-3-one (<b>1</b>) and (6<i>R</i>)-1-<i>O</i>-deacetylkhayanolide E (<b>2</b>), together with eleven known compounds (<b>3</b>-<b>13</b>), including additional limonoids, flavonoids, triterpenoids, steroids, and fatty acid. Their structures were determined using 1D- and 2D-NMR experiments, ESI mass spectrometry, and single crystal X-ray diffraction analysis. The antibacterial and antiplasmodial activities of the extracts, sub-extracts, fractions, and some of the isolated compounds were evaluated in known pathogenic strains, including <i>Staphylococcus aureus</i> and <i>P2023-01-01T00:00:00Z2023 Feb2025-04-26T00:05:04.272Z2025-02-18T23:57:44.861ZS-EPMC99661383683791710.3390/metabo13020298