{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bogdanova A"],"funding":["the strategic academic leadership program \"Priority 2030\""],"pagination":["3535"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9966984"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(4)"],"pubmed_abstract":["Biocompatible polyesters are widely used in biomedical applications, including sutures, orthopedic devices, drug delivery systems, and tissue engineering scaffolds. Blending polyesters with proteins is a common method of tuning biomaterial properties. Usually, it improves hydrophilicity, enhances cell adhesion, and accelerates biodegradation. However, inclusion of proteins to a polyester-based material typically reduces its mechanical properties. Here, we describe the physicochemical properties of an electrospun polylactic acid (PLA)-gelatin blend with a 9:1 PLA:gelatin ratio. We found that a small content (10 wt%) of gelatin does not affect the extensibility and strength of wet electrospun PLA mats but significantly accelerates their in vitro and in vivo decomposition. After a month, the "],"journal":["International journal of molecular sciences"],"pubmed_title":["Acceleration of Electrospun PLA Degradation by Addition of Gelatin."],"pmcid":["PMC9966984"],"funding_grant_id":["075-02-2021-1316"],"pubmed_authors":["Durymanov M","Bagrov D","Filkov G","Bogdanova A","Polyanskaya A","Volkova M","Klinov D","Pavlova E","Biryukova E","Trofimenko A"],"additional_accession":[]},"is_claimable":false,"name":"Acceleration of Electrospun PLA Degradation by Addition of Gelatin.","description":"Biocompatible polyesters are widely used in biomedical applications, including sutures, orthopedic devices, drug delivery systems, and tissue engineering scaffolds. Blending polyesters with proteins is a common method of tuning biomaterial properties. Usually, it improves hydrophilicity, enhances cell adhesion, and accelerates biodegradation. However, inclusion of proteins to a polyester-based material typically reduces its mechanical properties. Here, we describe the physicochemical properties of an electrospun polylactic acid (PLA)-gelatin blend with a 9:1 PLA:gelatin ratio. We found that a small content (10 wt%) of gelatin does not affect the extensibility and strength of wet electrospun PLA mats but significantly accelerates their in vitro and in vivo decomposition. After a month, the ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-05T14:19:57.672Z","creation":"2025-02-18T23:57:53.551Z"},"accession":"S-EPMC9966984","cross_references":{"pubmed":["36834947"],"doi":["10.3390/ijms24043535"]}}