biostudies-literatureBogdanova Athe strategic academic leadership program "Priority 2030"3535https://www.ebi.ac.uk/biostudies/studies/S-EPMC9966984biostudies-literatureUnknown24(4)Biocompatible polyesters are widely used in biomedical applications, including sutures, orthopedic devices, drug delivery systems, and tissue engineering scaffolds. Blending polyesters with proteins is a common method of tuning biomaterial properties. Usually, it improves hydrophilicity, enhances cell adhesion, and accelerates biodegradation. However, inclusion of proteins to a polyester-based material typically reduces its mechanical properties. Here, we describe the physicochemical properties of an electrospun polylactic acid (PLA)-gelatin blend with a 9:1 PLA:gelatin ratio. We found that a small content (10 wt%) of gelatin does not affect the extensibility and strength of wet electrospun PLA mats but significantly accelerates their in vitro and in vivo decomposition. After a month, the International journal of molecular sciencesAcceleration of Electrospun PLA Degradation by Addition of Gelatin.PMC9966984075-02-2021-1316Durymanov MBagrov DFilkov GBogdanova APolyanskaya AVolkova MKlinov DPavlova EBiryukova ETrofimenko AfalseAcceleration of Electrospun PLA Degradation by Addition of Gelatin.Biocompatible polyesters are widely used in biomedical applications, including sutures, orthopedic devices, drug delivery systems, and tissue engineering scaffolds. Blending polyesters with proteins is a common method of tuning biomaterial properties. Usually, it improves hydrophilicity, enhances cell adhesion, and accelerates biodegradation. However, inclusion of proteins to a polyester-based material typically reduces its mechanical properties. Here, we describe the physicochemical properties of an electrospun polylactic acid (PLA)-gelatin blend with a 9:1 PLA:gelatin ratio. We found that a small content (10 wt%) of gelatin does not affect the extensibility and strength of wet electrospun PLA mats but significantly accelerates their in vitro and in vivo decomposition. After a month, the 2023-01-01T00:00:00Z2023 Feb2025-04-05T14:19:57.672Z2025-02-18T23:57:53.551ZS-EPMC99669843683494710.3390/ijms24043535