{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ahmed MH"],"funding":["Marie Skłodowska-Curie"],"pagination":["455"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9967384"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(2)"],"pubmed_abstract":["Therapeutic antibodies targeting immune checkpoints have shown limited efficacy in clinical trials in glioblastoma (GBM) patients. Ultrasound-mediated blood-brain barrier opening (UMBO) using low-intensity pulsed ultrasound improved drug delivery to the brain. We explored the safety and the efficacy of UMBO plus immune checkpoint inhibitors in preclinical models of GBM. A blood-brain barrier (BBB) opening was performed using a 1 MHz preclinical ultrasound system in combination with 10 µL/g microbubbles. Brain penetration of immune checkpoint inhibitors was determined, and immune cell populations were evaluated using flow cytometry. The impact of repeated treatments on survival was determined. In syngeneic GL261-bearing immunocompetent mice, we showed that UMBO safely and repeatedly opened "],"journal":["Pharmaceutics"],"pubmed_title":["Low-Intensity Pulsed Ultrasound-Mediated Blood-Brain Barrier Opening Increases Anti-Programmed Death-Ligand 1 Delivery and Efficacy in Gl261 Mouse Model."],"pmcid":["PMC9967384"],"funding_grant_id":["#766069"],"pubmed_authors":["Santin M","Canney M","Zahr N","Sanson M","Guyonnet L","Petiet A","Ahmed MH","Mouton L","Lemaire N","Carpentier A","Quissac E","Idbaih A","Hernandez-Verdin I","Verreault M","Bouchoux G","Schmitt C","Guerin C"],"additional_accession":[]},"is_claimable":false,"name":"Low-Intensity Pulsed Ultrasound-Mediated Blood-Brain Barrier Opening Increases Anti-Programmed Death-Ligand 1 Delivery and Efficacy in Gl261 Mouse Model.","description":"Therapeutic antibodies targeting immune checkpoints have shown limited efficacy in clinical trials in glioblastoma (GBM) patients. Ultrasound-mediated blood-brain barrier opening (UMBO) using low-intensity pulsed ultrasound improved drug delivery to the brain. We explored the safety and the efficacy of UMBO plus immune checkpoint inhibitors in preclinical models of GBM. A blood-brain barrier (BBB) opening was performed using a 1 MHz preclinical ultrasound system in combination with 10 µL/g microbubbles. Brain penetration of immune checkpoint inhibitors was determined, and immune cell populations were evaluated using flow cytometry. The impact of repeated treatments on survival was determined. In syngeneic GL261-bearing immunocompetent mice, we showed that UMBO safely and repeatedly opened ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2026-04-08T14:39:53.6Z","creation":"2025-02-18T23:44:50.708Z"},"accession":"S-EPMC9967384","cross_references":{"pubmed":["36839777"],"doi":["10.3390/pharmaceutics15020455"]}}