{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(4)"],"submitter":["Couette M"],"funding":["APHP","SAMG"],"pubmed_abstract":["This study sought to link neurocognitive profiles in sickle cell disease (SCD) patients with clinical characteristics. We conducted a prospective cohort study of adults with SCD who underwent comprehensive neuropsychological assessment at the UMGGR clinic at Henri Mondor Hospital, Créteil (France). A cluster analysis was performed based on neuropsychological testing scores. The association between clusters and clinical profiles was assessed. Between 2017 and 2021, 79 patients with a mean age of 36 [range 19-65] years were included. On principal component analysis, a 5-factor model presented the best fit (Bartlett's sphericity test [χ<sup>2</sup> (171) = 1345; <i>p</i> < 0.001]), explaining 72% of the variance. The factors represent distinct cognitive domains and anatomical regions. On hier"],"journal":["Journal of clinical medicine"],"pagination":["1615"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9967394"],"repository":["biostudies-literature"],"pubmed_title":["Early Strokes Are Associated with More Global Cognitive Deficits in Adults with Sickle Cell Disease."],"pmcid":["PMC9967394"],"pubmed_authors":["Couette M","Mekontso-Dessap A","Kuo KHM","Bartolucci P","Forte S","Oudin Doglioni D","Calvet D"],"additional_accession":[]},"is_claimable":false,"name":"Early Strokes Are Associated with More Global Cognitive Deficits in Adults with Sickle Cell Disease.","description":"This study sought to link neurocognitive profiles in sickle cell disease (SCD) patients with clinical characteristics. We conducted a prospective cohort study of adults with SCD who underwent comprehensive neuropsychological assessment at the UMGGR clinic at Henri Mondor Hospital, Créteil (France). A cluster analysis was performed based on neuropsychological testing scores. The association between clusters and clinical profiles was assessed. Between 2017 and 2021, 79 patients with a mean age of 36 [range 19-65] years were included. On principal component analysis, a 5-factor model presented the best fit (Bartlett's sphericity test [χ<sup>2</sup> (171) = 1345; <i>p</i> < 0.001]), explaining 72% of the variance. The factors represent distinct cognitive domains and anatomical regions. On hier","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-08-17T03:05:19.845Z","creation":"2025-02-18T23:57:51.721Z"},"accession":"S-EPMC9967394","cross_references":{"pubmed":["36836150"],"doi":["10.3390/jcm12041615"]}}