biostudies-literatureUnknown12(4)Couette MAPHPSAMGThis study sought to link neurocognitive profiles in sickle cell disease (SCD) patients with clinical characteristics. We conducted a prospective cohort study of adults with SCD who underwent comprehensive neuropsychological assessment at the UMGGR clinic at Henri Mondor Hospital, Créteil (France). A cluster analysis was performed based on neuropsychological testing scores. The association between clusters and clinical profiles was assessed. Between 2017 and 2021, 79 patients with a mean age of 36 [range 19-65] years were included. On principal component analysis, a 5-factor model presented the best fit (Bartlett's sphericity test [χ² (171) = 1345; <i>p</i> < 0.001]), explaining 72% of the variance. The factors represent distinct cognitive domains and anatomical regions. On hierJournal of clinical medicine1615https://www.ebi.ac.uk/biostudies/studies/S-EPMC9967394biostudies-literatureEarly Strokes Are Associated with More Global Cognitive Deficits in Adults with Sickle Cell Disease.PMC9967394Couette MMekontso-Dessap AKuo KHMBartolucci PForte SOudin Doglioni DCalvet DfalseEarly Strokes Are Associated with More Global Cognitive Deficits in Adults with Sickle Cell Disease.This study sought to link neurocognitive profiles in sickle cell disease (SCD) patients with clinical characteristics. We conducted a prospective cohort study of adults with SCD who underwent comprehensive neuropsychological assessment at the UMGGR clinic at Henri Mondor Hospital, Créteil (France). A cluster analysis was performed based on neuropsychological testing scores. The association between clusters and clinical profiles was assessed. Between 2017 and 2021, 79 patients with a mean age of 36 [range 19-65] years were included. On principal component analysis, a 5-factor model presented the best fit (Bartlett's sphericity test [χ² (171) = 1345; <i>p</i> < 0.001]), explaining 72% of the variance. The factors represent distinct cognitive domains and anatomical regions. On hier2023-01-01T00:00:00Z2023 Feb2025-08-17T03:05:19.845Z2025-02-18T23:57:51.721ZS-EPMC99673943683615010.3390/jcm12041615