{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Leite AC"],"funding":["Fundação para a Ciência e Tecnologia"],"pagination":["4111"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9967508"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(4)"],"pubmed_abstract":["Cdh1p is one of the two substrate adaptor proteins of the anaphase promoting complex/cyclosome (APC/C), a ubiquitin ligase that regulates proteolysis during cell cycle. In this work, using a proteomic approach, we found 135 mitochondrial proteins whose abundance was significantly altered in the <i>cdh1</i>Δ mutant, with 43 up-regulated proteins and 92 down-regulated proteins. The group of significantly up-regulated proteins included subunits of the mitochondrial respiratory chain, enzymes from the tricarboxylic acid cycle and regulators of mitochondrial organization, suggesting a metabolic remodelling towards an increase in mitochondrial respiration. In accordance, mitochondrial oxygen consumption and Cytochrome <i>c</i> oxidase activity increased in Cdh1p-deficient cells. These effects se"],"journal":["International journal of molecular sciences"],"pubmed_title":["The APC/C Activator Cdh1p Plays a Role in Mitochondrial Metabolic Remodelling in Yeast."],"pmcid":["PMC9967508"],"funding_grant_id":["SFRH/BD/135921/2018","ROTEIRO/0028/2013; LISBOA-01-0145-FEDER-022125","IF/00889/2015","UIDB/04293/2020"],"pubmed_authors":["Pereira C","Barbedo M","Costa V","Leite AC"],"additional_accession":[]},"is_claimable":false,"name":"The APC/C Activator Cdh1p Plays a Role in Mitochondrial Metabolic Remodelling in Yeast.","description":"Cdh1p is one of the two substrate adaptor proteins of the anaphase promoting complex/cyclosome (APC/C), a ubiquitin ligase that regulates proteolysis during cell cycle. In this work, using a proteomic approach, we found 135 mitochondrial proteins whose abundance was significantly altered in the <i>cdh1</i>Δ mutant, with 43 up-regulated proteins and 92 down-regulated proteins. The group of significantly up-regulated proteins included subunits of the mitochondrial respiratory chain, enzymes from the tricarboxylic acid cycle and regulators of mitochondrial organization, suggesting a metabolic remodelling towards an increase in mitochondrial respiration. In accordance, mitochondrial oxygen consumption and Cytochrome <i>c</i> oxidase activity increased in Cdh1p-deficient cells. These effects se","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-04T21:47:16.258Z","creation":"2024-11-08T18:11:03.392Z"},"accession":"S-EPMC9967508","cross_references":{"pubmed":["36835555"],"doi":["10.3390/ijms24044111"]}}