biostudies-literatureUnknown11(2)Kodde CVaccination plays a key role in tackling the ongoing SARS-CoV-2 pandemic but data regarding the individual's protective antibody level are still pending. Our aim is to identify factors that influence antibody response following vaccination in healthcare workers. This single-center study was conducted at Evangelische Kliniken Gelsenkirchen, Germany. Healthcare workers were invited to answer a questionnaire about their vaccinations and adverse reactions. Subsequently, the level of anti-receptor binding domain (RBD) IgG antibody against SARS-CoV-2's spike protein through blood samples was measured. For statistics, we used a defined correlation of protection (CoP) and examined risk factors associated with being below the given CoP. A total of 645 employees were included and most were female (nVaccines451https://www.ebi.ac.uk/biostudies/studies/S-EPMC9967627biostudies-literatureFactors Influencing Antibody Response to SARS-CoV-2 Vaccination.PMC9967627Balamitsa ETafelski SBonsignore MKodde CNachtigall IfalseFactors Influencing Antibody Response to SARS-CoV-2 Vaccination.Vaccination plays a key role in tackling the ongoing SARS-CoV-2 pandemic but data regarding the individual's protective antibody level are still pending. Our aim is to identify factors that influence antibody response following vaccination in healthcare workers. This single-center study was conducted at Evangelische Kliniken Gelsenkirchen, Germany. Healthcare workers were invited to answer a questionnaire about their vaccinations and adverse reactions. Subsequently, the level of anti-receptor binding domain (RBD) IgG antibody against SARS-CoV-2's spike protein through blood samples was measured. For statistics, we used a defined correlation of protection (CoP) and examined risk factors associated with being below the given CoP. A total of 645 employees were included and most were female (n2023-01-01T00:00:00Z2023 Feb2025-04-04T21:47:24.708Z2025-04-04T21:47:24.708ZS-EPMC99676273685132610.3390/vaccines11020451