{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["18(2)"],"submitter":["Li H"],"pubmed_abstract":["Multiple chromatin modifiers associated with H3K9me3 play important roles in the transition from embryonic stem cells to 2-cell (2C)-like cells. However, it remains elusive how H3K9me3 is remodeled and its association with totipotency. Here, we integrated transcriptome and H3K9me3 profiles to conduct a detailed comparison of 2C embryos and 2C-like cells. Globally, H3K9me3 is highly preserved and H3K9me3 dynamics within the gene locus is not associated with gene expression change during 2C-like transition. Promoter-deposited H3K9me3 plays non-repressive roles in the activation of genes during 2C-like transition. In contrast, transposable elements, residing in the nearby regions of up-regulated genes, undergo extensive elimination of H3K9me3 and are tended to be induced in 2C-like transition"],"journal":["Stem cell reports"],"pagination":["449-462"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9968986"],"repository":["biostudies-literature"],"pubmed_title":["Remodeling of H3K9me3 during the pluripotent to totipotent-like state transition."],"pmcid":["PMC9968986"],"pubmed_authors":["Li H","Shen L","Wu L","Dong Y","Liang Y","Zuo Y","Xiao Y","Abudureheman A","Lin Z","Wang H","Le R","Li Y","Huang Y","Zhang Y","Su Z","Zhang C","Xi C","Sun J","Kong X","Gao S","Yin J"],"additional_accession":[]},"is_claimable":false,"name":"Remodeling of H3K9me3 during the pluripotent to totipotent-like state transition.","description":"Multiple chromatin modifiers associated with H3K9me3 play important roles in the transition from embryonic stem cells to 2-cell (2C)-like cells. However, it remains elusive how H3K9me3 is remodeled and its association with totipotency. Here, we integrated transcriptome and H3K9me3 profiles to conduct a detailed comparison of 2C embryos and 2C-like cells. Globally, H3K9me3 is highly preserved and H3K9me3 dynamics within the gene locus is not associated with gene expression change during 2C-like transition. Promoter-deposited H3K9me3 plays non-repressive roles in the activation of genes during 2C-like transition. In contrast, transposable elements, residing in the nearby regions of up-regulated genes, undergo extensive elimination of H3K9me3 and are tended to be induced in 2C-like transition","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-26T10:20:20.171Z","creation":"2025-04-06T13:17:41.799Z"},"accession":"S-EPMC9968986","cross_references":{"pubmed":["36638787"],"doi":["10.1016/j.stemcr.2022.12.006"]}}