{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["33(1)"],"submitter":["Lai EF"],"pubmed_abstract":["<h4>Introduction</h4>Few studies have compared within-patient variability measures of tacrolimus trough levels by formulation and assessed within-patient variability on outcomes of kidney transplant recipients.<h4>Research questions</h4>(1) To compare within-patient variability of trough levels when converting from twice-daily to once-daily tacrolimus using standard deviation, coefficient of variation, and intrapatient variability percent. (2) To use the 3 measures of variability to examine the relationship between tacrolimus once-daily within-patient variability and total graft failure (i.e., return to chronic dialysis, pre-emptive retransplant, death with graft function).<h4>Design</h4>In this observational cohort study, within-patient variability of trough levels pre- and post-conversio"],"journal":["Progress in transplantation (Aliso Viejo, Calif.)"],"pagination":["34-42"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9968997"],"repository":["biostudies-literature"],"pubmed_title":["Tacrolimus Formulation, Exposure Variability, and Outcomes in Kidney Transplant Recipients."],"pmcid":["PMC9968997"],"pubmed_authors":["Famure O","Li Y","Lai EF","Kim SJ","Nguyen HT"],"additional_accession":[]},"is_claimable":false,"name":"Tacrolimus Formulation, Exposure Variability, and Outcomes in Kidney Transplant Recipients.","description":"<h4>Introduction</h4>Few studies have compared within-patient variability measures of tacrolimus trough levels by formulation and assessed within-patient variability on outcomes of kidney transplant recipients.<h4>Research questions</h4>(1) To compare within-patient variability of trough levels when converting from twice-daily to once-daily tacrolimus using standard deviation, coefficient of variation, and intrapatient variability percent. (2) To use the 3 measures of variability to examine the relationship between tacrolimus once-daily within-patient variability and total graft failure (i.e., return to chronic dialysis, pre-emptive retransplant, death with graft function).<h4>Design</h4>In this observational cohort study, within-patient variability of trough levels pre- and post-conversio","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-04-04T21:48:11.588Z","creation":"2025-04-04T21:48:11.588Z"},"accession":"S-EPMC9968997","cross_references":{"pubmed":["36562176"],"doi":["10.1177/15269248221145044"]}}