biostudies-literatureUnknown33(1)Lai EF<h4>Introduction</h4>Few studies have compared within-patient variability measures of tacrolimus trough levels by formulation and assessed within-patient variability on outcomes of kidney transplant recipients.<h4>Research questions</h4>(1) To compare within-patient variability of trough levels when converting from twice-daily to once-daily tacrolimus using standard deviation, coefficient of variation, and intrapatient variability percent. (2) To use the 3 measures of variability to examine the relationship between tacrolimus once-daily within-patient variability and total graft failure (i.e., return to chronic dialysis, pre-emptive retransplant, death with graft function).<h4>Design</h4>In this observational cohort study, within-patient variability of trough levels pre- and post-conversioProgress in transplantation (Aliso Viejo, Calif.)34-42https://www.ebi.ac.uk/biostudies/studies/S-EPMC9968997biostudies-literatureTacrolimus Formulation, Exposure Variability, and Outcomes in Kidney Transplant Recipients.PMC9968997Famure OLi YLai EFKim SJNguyen HTfalseTacrolimus Formulation, Exposure Variability, and Outcomes in Kidney Transplant Recipients.<h4>Introduction</h4>Few studies have compared within-patient variability measures of tacrolimus trough levels by formulation and assessed within-patient variability on outcomes of kidney transplant recipients.<h4>Research questions</h4>(1) To compare within-patient variability of trough levels when converting from twice-daily to once-daily tacrolimus using standard deviation, coefficient of variation, and intrapatient variability percent. (2) To use the 3 measures of variability to examine the relationship between tacrolimus once-daily within-patient variability and total graft failure (i.e., return to chronic dialysis, pre-emptive retransplant, death with graft function).<h4>Design</h4>In this observational cohort study, within-patient variability of trough levels pre- and post-conversio2023-01-01T00:00:00Z2023 Mar2025-04-04T21:48:11.588Z2025-04-04T21:48:11.588ZS-EPMC99689973656217610.1177/15269248221145044