biostudies-literatureChan CKNIA NIH HHS1415-1426https://www.ebi.ac.uk/biostudies/studies/S-EPMC9969328biostudies-literatureUnknown86(3)<h4>Background</h4>Neuropsychiatric symptoms (NPS) among cognitively normal older adults are increasingly recognized as risk factors for cognitive decline and impairment. However, the underlying mechanisms remain unclear.<h4>Objective</h4>To examine whether biomarkers of Alzheimer's disease (amyloid burden) and cerebrovascular disease (white matter hyperintensity (WMH) volume) modify the association between NPS and cognitive decline among cognitively unimpaired older adults.<h4>Methods</h4>Analyses included 193 cognitively unimpaired participants (M age = 70 years) from the BIOCARD study, including 148 with PET amyloid and WMH biomarker data. NPS were measured with Neuropsychiatric Inventory and Geriatric Depression Scale scores. Linear mixed effects models were used to examine the associaJournal of Alzheimer's disease : JADAssociation Between Late-Life Neuropsychiatric Symptoms and Cognitive Decline in Relation to White Matter Hyperintensities and Amyloid Burden.PMC9969328P30 AG066507U19 AG033655Albert MWang MCChan CKZhu YPettigrew CRosenberg PBSoldan ABIOCARD Research TeamfalseAssociation Between Late-Life Neuropsychiatric Symptoms and Cognitive Decline in Relation to White Matter Hyperintensities and Amyloid Burden.<h4>Background</h4>Neuropsychiatric symptoms (NPS) among cognitively normal older adults are increasingly recognized as risk factors for cognitive decline and impairment. However, the underlying mechanisms remain unclear.<h4>Objective</h4>To examine whether biomarkers of Alzheimer's disease (amyloid burden) and cerebrovascular disease (white matter hyperintensity (WMH) volume) modify the association between NPS and cognitive decline among cognitively unimpaired older adults.<h4>Methods</h4>Analyses included 193 cognitively unimpaired participants (M age = 70 years) from the BIOCARD study, including 148 with PET amyloid and WMH biomarker data. NPS were measured with Neuropsychiatric Inventory and Geriatric Depression Scale scores. Linear mixed effects models were used to examine the associa2022-01-01T00:00:00Z20222025-04-04T00:36:16.244Z2025-04-04T00:36:16.244ZS-EPMC99693283521337010.3233/JAD-21526710.3233/jad-215267