{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lee H"],"funding":["NCATS NIH HHS","NCCIH NIH HHS"],"pagination":["119512"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9969358"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["261"],"pubmed_abstract":["The choroid plexus (ChP) of the cerebral ventricles is a source of cerebrospinal fluid (CSF) production and also plays a key role in immune surveillance at the level of blood-to-CSF-barrier (BCSFB). In this study, we quantify ChP blood perfusion and BCSFB mediated water exchange from arterial blood into ventricular CSF using non-invasive continuous arterial spin labelling magnetic resonance imaging (CASL-MRI). Systemic administration of anti-diuretic hormone (vasopressin) was used to validate BCSFB water flow as a metric of choroidal CSF secretory function. To further investigate the coupling between ChP blood perfusion and BCSFB water flow, we characterized the effects of two anesthetic regimens known to have large-scale differential effects on cerebral blood flow. For quantification of C"],"journal":["NeuroImage"],"pubmed_title":["Choroid plexus tissue perfusion and blood to CSF barrier function in rats measured with continuous arterial spin labeling."],"pmcid":["PMC9969358"],"funding_grant_id":["R01 AT011419","UL1 TR001863"],"pubmed_authors":["MacIntosh BJ","Koundal S","Lee H","Ozturk B","Rothman D","Benveniste H","Stringer MS"],"additional_accession":[]},"is_claimable":false,"name":"Choroid plexus tissue perfusion and blood to CSF barrier function in rats measured with continuous arterial spin labeling.","description":"The choroid plexus (ChP) of the cerebral ventricles is a source of cerebrospinal fluid (CSF) production and also plays a key role in immune surveillance at the level of blood-to-CSF-barrier (BCSFB). In this study, we quantify ChP blood perfusion and BCSFB mediated water exchange from arterial blood into ventricular CSF using non-invasive continuous arterial spin labelling magnetic resonance imaging (CASL-MRI). Systemic administration of anti-diuretic hormone (vasopressin) was used to validate BCSFB water flow as a metric of choroidal CSF secretory function. To further investigate the coupling between ChP blood perfusion and BCSFB water flow, we characterized the effects of two anesthetic regimens known to have large-scale differential effects on cerebral blood flow. For quantification of C","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-04T00:35:56.123Z","creation":"2025-04-04T00:35:56.123Z"},"accession":"S-EPMC9969358","cross_references":{"pubmed":["35882269"],"doi":["10.1016/j.neuroimage.2022.119512"]}}