{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Siegel MR"],"funding":["Centers for Disease Control and Prevention","NIEHS NIH HHS","Intramural CDC HHS"],"pagination":["30-40"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9969860"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["66(1)"],"pubmed_abstract":["<h4>Background</h4>Few studies have evaluated birth defects among children of firefighters. We investigated associations between birth defects and paternal work as a firefighter compared to work in non-firefighting and police officer occupations.<h4>Methods</h4>We analyzed 1997-2011 data from the multi-site case-control National Birth Defects Prevention Study. Cases included fetuses or infants with major structural birth defects and controls included a random sample of live-born infants without major birth defects. Mothers of infants self-reported information about parents' occupations held during pregnancy. We investigated associations between paternal firefighting and birth defect groups using logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Referent groups included families reporting fathers working non-firefighting and police officer jobs.<h4>Results</h4>Occupational groups included 227 firefighters, 36,285 non-firefighters, and 433 police officers. Twenty-nine birth defects were analyzed. In adjusted analyses, fathers of children with total anomalous pulmonary venous return (TAPVR; OR = 3.1; 95% CI = 1.1-8.7), cleft palate (OR = 1.8; 95% CI = 1.0-3.3), cleft lip (OR = 2.2; 95% CI = 1.2-4.2), and transverse limb deficiency (OR = 2.2; 95% CI = 1.1-4.7) were more likely than fathers of controls to be firefighters, versus non-firefighters. In police-referent analyses, fathers of children with cleft palate were 2.4 times more likely to be firefighters than fathers of controls (95% CI = 1.1-5.4).<h4>Conclusions</h4>Paternal firefighting may be associated with an elevated risk of birth defects in offspring. Additional studies are warranted to replicate these findings. Further research may contribute to a greater understanding of the reproductive health of firefighters and their families for guiding workplace practices."],"journal":["American journal of industrial medicine"],"pubmed_title":["Birth defects associated with paternal firefighting in the National Birth Defects Prevention Study."],"pmcid":["PMC9969860"],"funding_grant_id":["CC999999","P30 ES010126"],"pubmed_authors":["Hollerbach BS","Siegel MR","Omari A","National Birth Defects Prevention Study","Rocheleau CM","Almli LM","Olshan AF","Jahnke SA"],"additional_accession":[]},"is_claimable":false,"name":"Birth defects associated with paternal firefighting in the National Birth Defects Prevention Study.","description":"<h4>Background</h4>Few studies have evaluated birth defects among children of firefighters. We investigated associations between birth defects and paternal work as a firefighter compared to work in non-firefighting and police officer occupations.<h4>Methods</h4>We analyzed 1997-2011 data from the multi-site case-control National Birth Defects Prevention Study. Cases included fetuses or infants with major structural birth defects and controls included a random sample of live-born infants without major birth defects. Mothers of infants self-reported information about parents' occupations held during pregnancy. We investigated associations between paternal firefighting and birth defect groups using logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Referent groups included families reporting fathers working non-firefighting and police officer jobs.<h4>Results</h4>Occupational groups included 227 firefighters, 36,285 non-firefighters, and 433 police officers. Twenty-nine birth defects were analyzed. In adjusted analyses, fathers of children with total anomalous pulmonary venous return (TAPVR; OR = 3.1; 95% CI = 1.1-8.7), cleft palate (OR = 1.8; 95% CI = 1.0-3.3), cleft lip (OR = 2.2; 95% CI = 1.2-4.2), and transverse limb deficiency (OR = 2.2; 95% CI = 1.1-4.7) were more likely than fathers of controls to be firefighters, versus non-firefighters. In police-referent analyses, fathers of children with cleft palate were 2.4 times more likely to be firefighters than fathers of controls (95% CI = 1.1-5.4).<h4>Conclusions</h4>Paternal firefighting may be associated with an elevated risk of birth defects in offspring. Additional studies are warranted to replicate these findings. Further research may contribute to a greater understanding of the reproductive health of firefighters and their families for guiding workplace practices.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-04T00:35:55.009Z","creation":"2025-02-18T23:26:01.31Z"},"accession":"S-EPMC9969860","cross_references":{"pubmed":["36345775"],"doi":["10.1002/ajim.23441"]}}