{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["18(2)"],"submitter":["Baunez C"],"pubmed_abstract":["We provide a novel way to correct the effective reproduction number for the time-varying amount of tests, using the acceleration index (Baunez et al., 2021) as a simple measure of viral spread dynamics. Not correcting results in the reproduction number being a biased estimate of viral acceleration and we provide a formal decomposition of the resulting bias, involving the useful notions of test and infectivity intensities. When applied to French data for the COVID-19 pandemic (May 13, 2020-October 26, 2022), our decomposition shows that the reproduction number, when considered alone, characteristically underestimates the resurgence of the pandemic, compared to the acceleration index which accounts for the time-varying volume of tests. Because the acceleration index aggregates all relevant i"],"journal":["PloS one"],"pagination":["e0281943"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9970098"],"repository":["biostudies-literature"],"pubmed_title":["Correcting the reproduction number for time-varying tests: A proposal and an application to COVID-19 in France."],"pmcid":["PMC9970098"],"pubmed_authors":["Pintus ML","Pintus PA","Degoulet M","Teschl M","Baunez C","Luchini S"],"additional_accession":[]},"is_claimable":false,"name":"Correcting the reproduction number for time-varying tests: A proposal and an application to COVID-19 in France.","description":"We provide a novel way to correct the effective reproduction number for the time-varying amount of tests, using the acceleration index (Baunez et al., 2021) as a simple measure of viral spread dynamics. Not correcting results in the reproduction number being a biased estimate of viral acceleration and we provide a formal decomposition of the resulting bias, involving the useful notions of test and infectivity intensities. When applied to French data for the COVID-19 pandemic (May 13, 2020-October 26, 2022), our decomposition shows that the reproduction number, when considered alone, characteristically underestimates the resurgence of the pandemic, compared to the acceleration index which accounts for the time-varying volume of tests. Because the acceleration index aggregates all relevant i","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-18T14:21:20.93Z","creation":"2025-04-07T00:29:32.324Z"},"accession":"S-EPMC9970098","cross_references":{"pubmed":["36848355"],"doi":["10.1371/journal.pone.0281943"]}}