{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Campagnola L"],"funding":["NIDA NIH HHS","NIA NIH HHS","NIMH NIH HHS"],"pagination":["eabj5861"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9970277"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["375(6585)"],"pubmed_abstract":["We present a unique, extensive, and open synaptic physiology analysis platform and dataset. Through its application, we reveal principles that relate cell type to synaptic properties and intralaminar circuit organization in the mouse and human cortex. The dynamics of excitatory synapses align with the postsynaptic cell subclass, whereas inhibitory synapse dynamics partly align with presynaptic cell subclass but with considerable overlap. Synaptic properties are heterogeneous in most subclass-to-subclass connections. The two main axes of heterogeneity are strength and variability. Cell subclasses divide along the variability axis, whereas the strength axis accounts for substantial heterogeneity within the subclass. In the human cortex, excitatory-to-excitatory synaptic dynamics are distinct"],"journal":["Science (New York, N.Y.)"],"pubmed_title":["Local connectivity and synaptic dynamics in mouse and human neocortex."],"pmcid":["PMC9970277"],"funding_grant_id":["RF1 MH121274","U19 MH114830","R01 DA036909","U01 MH114812","U01 MH105982","P30 AG066509"],"pubmed_authors":["Sorensen S","Ransford S","Gwinn RP","Shi S","Goldy J","Clark M","Silbergeld DL","Williams G","Koch C","Ito S","Arkhipov A","Braun T","Andrade J","Berry K","Pham T","Larsen R","Ko AL","Davoudian P","Gary A","Wakeman W","Jarsky T","Ngo K","Maxwell M","Sandman D","Chartrand T","Alfiler L","Gorham M","Walker M","Wadhwani K","Dingman Lee S","Bomben J","Ellenbogen R","Sulc J","Dotson N","Murphy G","Seeman SC","Potekhina L","Carey D","Teeter C","Daigle TL","Nicovich PR","Radaelli C","Ellingwood L","Tung H","Campagnola L","Dalley R","Zeng H","Alice M","Tieu M","Casper T","Kroll M","Pom CA","Henry A","Gloe J","Kim L","Hejazinia N","Feng D","Hage T","Bohn P","Brouner K","Sunkin S","Lein E","Enstrom R","Farrell C","Tasic B","Esposito L","Hupp M","Kim MH","Siverts L","Crichton K","Ojemann JG","Hoggarth A","McMillen D","Slaughterbeck C","Trinh J","Phillips J","D'Orazi FD","Smith K","Cobb C","Gamlin C","Szafer A","Kebede S","Bernard A","Ruiz A","McGraw M","Keene CD","Egdorf T","Schroedter M","Dee N"],"additional_accession":[]},"is_claimable":false,"name":"Local connectivity and synaptic dynamics in mouse and human neocortex.","description":"We present a unique, extensive, and open synaptic physiology analysis platform and dataset. Through its application, we reveal principles that relate cell type to synaptic properties and intralaminar circuit organization in the mouse and human cortex. The dynamics of excitatory synapses align with the postsynaptic cell subclass, whereas inhibitory synapse dynamics partly align with presynaptic cell subclass but with considerable overlap. Synaptic properties are heterogeneous in most subclass-to-subclass connections. The two main axes of heterogeneity are strength and variability. Cell subclasses divide along the variability axis, whereas the strength axis accounts for substantial heterogeneity within the subclass. In the human cortex, excitatory-to-excitatory synaptic dynamics are distinct","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-04T00:35:53.67Z","creation":"2025-04-04T00:35:53.67Z"},"accession":"S-EPMC9970277","cross_references":{"pubmed":["35271334"],"doi":["10.1126/science.abj5861"]}}