{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(3)"],"submitter":["de Sousa DMB"],"pubmed_abstract":["In Alzheimer's disease (AD), platelets become dysfunctional and might contribute to amyloid beta deposition. Here, we depleted platelets in one-year-old APP Swedish PS1 dE9 (APP-PS1) transgenic mice for five days, using intraperitoneal injections of an anti-CD42b antibody, and assessed changes in cerebral amyloidosis, plaque-associated neuritic dystrophy and gliosis. In APP-PS1 female mice, platelet depletion shifted amyloid plaque size distribution towards bigger plaques and increased neuritic dystrophy in the hippocampus. In platelet-depleted females, plaque-associated Iba1+ microglia had lower amounts of fibrillar amyloid beta cargo and GFAP+ astrocytic processes showed a higher overlap with thioflavin S+ amyloid plaques. In contrast to the popular hypothesis that platelets foster plaqu"],"journal":["Aging"],"pagination":["630-649"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9970308"],"repository":["biostudies-literature"],"pubmed_title":["Immune-mediated platelet depletion augments Alzheimer's disease neuropathological hallmarks in APP-PS1 mice."],"pmcid":["PMC9970308"],"pubmed_authors":["Benedetti A","Mrowetz H","Unger MS","Aigner L","Altendorfer B","Kniewallner KM","de Sousa DMB","Schallmoser K"],"additional_accession":[]},"is_claimable":false,"name":"Immune-mediated platelet depletion augments Alzheimer's disease neuropathological hallmarks in APP-PS1 mice.","description":"In Alzheimer's disease (AD), platelets become dysfunctional and might contribute to amyloid beta deposition. Here, we depleted platelets in one-year-old APP Swedish PS1 dE9 (APP-PS1) transgenic mice for five days, using intraperitoneal injections of an anti-CD42b antibody, and assessed changes in cerebral amyloidosis, plaque-associated neuritic dystrophy and gliosis. In APP-PS1 female mice, platelet depletion shifted amyloid plaque size distribution towards bigger plaques and increased neuritic dystrophy in the hippocampus. In platelet-depleted females, plaque-associated Iba1+ microglia had lower amounts of fibrillar amyloid beta cargo and GFAP+ astrocytic processes showed a higher overlap with thioflavin S+ amyloid plaques. In contrast to the popular hypothesis that platelets foster plaqu","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-05-29T19:45:06.816Z","creation":"2025-05-29T19:45:06.816Z"},"accession":"S-EPMC9970308","cross_references":{"pubmed":["36734880"],"doi":["10.18632/aging.204502"]}}