biostudies-literatureKahr MKGerman Research Foundation (Deutsche Forschungsgemeinschaft DFGTexas Medical Center Digestive Disease CenterU.S. Department of Health and Human Services, National Institutes of Health NIH/NICHDNICHD NIH HHSNIDDK NIH HHS400-406https://www.ebi.ac.uk/biostudies/studies/S-EPMC9970758biostudies-literatureUnknown40(4)<h4>Objective</h4> Obesity in pregnancy bears unique maternal and fetal risks. Obesity has also been associated with chronic inflammation, including elevated serum levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). Higher serum lipopolysaccharide (LPS) levels have been implicated in driving this inflammation, a phenomenon called metabolic endotoxemia (ME). GLP-2, a proglucagon-derived peptide, is believed to be integral in maintaining the integrity of the intestine in the face of LPS-mediated endotoxemia. We hypothesized that obesity and/or excess weight gain in pregnancy would be associated with an increase in maternal and neonatal markers of ME, as well as GLP-2.<h4>Study design</h4> Paired maternal and neonatal (cord blood) serum samples (<i>n</i> = 159) were obtained fAmerican journal of perinatologySERUM GLP-2 is Increased in Association with Excess Gestational Weight Gain.PMC9970758SA 2795/2–1R00HD075858–03R00HD075858-03P30DK56338R00 HD075858P30 DK056338SA 2795/2-1Suter MAWhitham MGalindo MHu MKahr MKAagaard KMAntony KMfalseSERUM GLP-2 is Increased in Association with Excess Gestational Weight Gain.<h4>Objective</h4> Obesity in pregnancy bears unique maternal and fetal risks. Obesity has also been associated with chronic inflammation, including elevated serum levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). Higher serum lipopolysaccharide (LPS) levels have been implicated in driving this inflammation, a phenomenon called metabolic endotoxemia (ME). GLP-2, a proglucagon-derived peptide, is believed to be integral in maintaining the integrity of the intestine in the face of LPS-mediated endotoxemia. We hypothesized that obesity and/or excess weight gain in pregnancy would be associated with an increase in maternal and neonatal markers of ME, as well as GLP-2.<h4>Study design</h4> Paired maternal and neonatal (cord blood) serum samples (<i>n</i> = 159) were obtained f2023-01-01T00:00:00Z2023 Mar2025-04-04T21:47:52.926Z2025-04-04T21:47:52.926ZS-EPMC99707583394064410.1055/s-0041-1728828