{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kim D"],"funding":["Ministry of Science and ICT","Ministry of Oceans and Fisheries","National Research Foundation of Korea"],"pagination":["141-147"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9970833"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(2)"],"pubmed_abstract":["Antibiotic resistance has emerged as a global threat to modern healthcare systems and has nullified many commonly used antibiotics. β-Lactam antibiotics are among the most successful and occupy approximately two-thirds of the prescription antibiotic market. They inhibit the synthesis of the peptidoglycan layer in the bacterial cell wall by mimicking the D-Ala-D-Ala in the pentapeptide crosslinking neighboring glycan chains. To date, various β-lactam antibiotics have been developed to increase the spectrum of activity and evade drug resistance. This review emphasizes the three-dimensional structural characteristics of β-lactam antibiotics regarding the overall scaffold, working mechanism, chemical diversity, and hydrolysis mechanism by β-lactamases. The structural insight into various β-lactams will provide an in-depth understanding of the antibacterial efficacy and susceptibility to drug resistance in multidrug-resistant bacteria and help to develop better β-lactam antibiotics and inhibitors."],"journal":["Biomolecules & therapeutics"],"pubmed_title":["Structural Insights for β-Lactam Antibiotics."],"pmcid":["PMC9970833"],"funding_grant_id":["NRF-2017M3A9E4078014 and NRF-2017M3A9E4078017","20170305"],"pubmed_authors":["Kim S","Kim D","Park H","Jang KM","Kwak K","Lee SH","Kwon Y","Kim Y","Lee H","Kang LW","Lee JH"],"additional_accession":[]},"is_claimable":false,"name":"Structural Insights for β-Lactam Antibiotics.","description":"Antibiotic resistance has emerged as a global threat to modern healthcare systems and has nullified many commonly used antibiotics. β-Lactam antibiotics are among the most successful and occupy approximately two-thirds of the prescription antibiotic market. They inhibit the synthesis of the peptidoglycan layer in the bacterial cell wall by mimicking the D-Ala-D-Ala in the pentapeptide crosslinking neighboring glycan chains. To date, various β-lactam antibiotics have been developed to increase the spectrum of activity and evade drug resistance. This review emphasizes the three-dimensional structural characteristics of β-lactam antibiotics regarding the overall scaffold, working mechanism, chemical diversity, and hydrolysis mechanism by β-lactamases. The structural insight into various β-lactams will provide an in-depth understanding of the antibacterial efficacy and susceptibility to drug resistance in multidrug-resistant bacteria and help to develop better β-lactam antibiotics and inhibitors.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-04-19T02:43:43.986Z","creation":"2025-02-19T04:54:58.315Z"},"accession":"S-EPMC9970833","cross_references":{"pubmed":["36788654"],"doi":["10.4062/biomolther.2023.008"]}}