{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Linders DGJ"],"funding":["Foundation for the National Institutes of Health","NCI NIH HHS"],"pagination":["58-73"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9971096"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(1)"],"pubmed_abstract":["The majority of breast cancer patients is treated with breast-conserving surgery (BCS) combined with adjuvant radiation therapy. Up to 40% of patients has a tumor-positive resection margin after BCS, which necessitates re-resection or additional boost radiation. Cathepsin-targeted near-infrared fluorescence imaging during BCS could be used to detect residual cancer in the surgical cavity and guide additional resection, thereby preventing tumor-positive resection margins and associated mutilating treatments. The cysteine cathepsins are a family of proteases that play a major role in normal cellular physiology and neoplastic transformation. In breast cancer, the increased enzymatic activity and aberrant localization of many of the cysteine cathepsins drive tumor progression, proliferation, i"],"journal":["Molecular imaging and biology"],"pubmed_title":["Cysteine Cathepsins in Breast Cancer: Promising Targets for Fluorescence-Guided Surgery."],"pmcid":["PMC9971096"],"funding_grant_id":["5R01CA246678","R01 CA246678"],"pubmed_authors":["Bijlstra OD","Valentijn ARPM","Straight B","Hilling DE","Basilion JP","Vahrmeijer AL","Fallert LC","Burggraaf J","March TL","Linders DGJ","Walker E","Pool M","Kuppen PJK"],"additional_accession":[]},"is_claimable":false,"name":"Cysteine Cathepsins in Breast Cancer: Promising Targets for Fluorescence-Guided Surgery.","description":"The majority of breast cancer patients is treated with breast-conserving surgery (BCS) combined with adjuvant radiation therapy. Up to 40% of patients has a tumor-positive resection margin after BCS, which necessitates re-resection or additional boost radiation. Cathepsin-targeted near-infrared fluorescence imaging during BCS could be used to detect residual cancer in the surgical cavity and guide additional resection, thereby preventing tumor-positive resection margins and associated mutilating treatments. The cysteine cathepsins are a family of proteases that play a major role in normal cellular physiology and neoplastic transformation. In breast cancer, the increased enzymatic activity and aberrant localization of many of the cysteine cathepsins drive tumor progression, proliferation, i","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-19T02:43:19.549Z","creation":"2025-02-19T04:54:23.698Z"},"accession":"S-EPMC9971096","cross_references":{"pubmed":["36002710"],"doi":["10.1007/s11307-022-01768-4"]}}