biostudies-literatureLinders DGJFoundation for the National Institutes of HealthNCI NIH HHS58-73https://www.ebi.ac.uk/biostudies/studies/S-EPMC9971096biostudies-literatureUnknown25(1)The majority of breast cancer patients is treated with breast-conserving surgery (BCS) combined with adjuvant radiation therapy. Up to 40% of patients has a tumor-positive resection margin after BCS, which necessitates re-resection or additional boost radiation. Cathepsin-targeted near-infrared fluorescence imaging during BCS could be used to detect residual cancer in the surgical cavity and guide additional resection, thereby preventing tumor-positive resection margins and associated mutilating treatments. The cysteine cathepsins are a family of proteases that play a major role in normal cellular physiology and neoplastic transformation. In breast cancer, the increased enzymatic activity and aberrant localization of many of the cysteine cathepsins drive tumor progression, proliferation, iMolecular imaging and biologyCysteine Cathepsins in Breast Cancer: Promising Targets for Fluorescence-Guided Surgery.PMC99710965R01CA246678R01 CA246678Bijlstra ODValentijn ARPMStraight BHilling DEBasilion JPVahrmeijer ALFallert LCBurggraaf JMarch TLLinders DGJWalker EPool MKuppen PJKfalseCysteine Cathepsins in Breast Cancer: Promising Targets for Fluorescence-Guided Surgery.The majority of breast cancer patients is treated with breast-conserving surgery (BCS) combined with adjuvant radiation therapy. Up to 40% of patients has a tumor-positive resection margin after BCS, which necessitates re-resection or additional boost radiation. Cathepsin-targeted near-infrared fluorescence imaging during BCS could be used to detect residual cancer in the surgical cavity and guide additional resection, thereby preventing tumor-positive resection margins and associated mutilating treatments. The cysteine cathepsins are a family of proteases that play a major role in normal cellular physiology and neoplastic transformation. In breast cancer, the increased enzymatic activity and aberrant localization of many of the cysteine cathepsins drive tumor progression, proliferation, i2023-01-01T00:00:00Z2023 Feb2025-04-19T02:43:19.549Z2025-02-19T04:54:23.698ZS-EPMC99710963600271010.1007/s11307-022-01768-4