biostudies-literatureStewart MJU.S. Department of Defense (DOD) Chronic Pain Management Research Program (CPMRP) Investigator-Initiated Research AwardNHLBI NIH HHSNational Institutes of Health3326https://www.ebi.ac.uk/biostudies/studies/S-EPMC9971260biostudies-literatureUnknown13(1)The growing opioid use and overdose crisis in the US is closely related to the abuse of pain medications. Particularly for postoperative pain (POP), ~ 310 million major surgeries are performed globally per year. Most patients undergoing surgical procedures experience acute POP, and ~ 75% of those with POP report the severity as moderate, severe, or extreme. Opioid analgesics are the mainstay for POP management. It is highly desirable to develop a truly effective and safe non-opioid analgesic to treat POP and other forms of pain. Notably, microsomal prostaglandin E2 (PGE₂) synthase-1 (mPGES-1) was once proposed as a potentially promising target for a next generation of anti-inflammatory drugs based on studies in mPGES-1 knockouts. However, to the best of our knowledge, no studiesScientific reportsAnalgesic effects of a highly selective mPGES-1 inhibitor.PMC9971260W81XWH2211000U01 HL152392Loftin CDWeaver LMKyomuhangi AZhan CGStewart MJDing KZheng FfalseAnalgesic effects of a highly selective mPGES-1 inhibitor.The growing opioid use and overdose crisis in the US is closely related to the abuse of pain medications. Particularly for postoperative pain (POP), ~ 310 million major surgeries are performed globally per year. Most patients undergoing surgical procedures experience acute POP, and ~ 75% of those with POP report the severity as moderate, severe, or extreme. Opioid analgesics are the mainstay for POP management. It is highly desirable to develop a truly effective and safe non-opioid analgesic to treat POP and other forms of pain. Notably, microsomal prostaglandin E2 (PGE₂) synthase-1 (mPGES-1) was once proposed as a potentially promising target for a next generation of anti-inflammatory drugs based on studies in mPGES-1 knockouts. However, to the best of our knowledge, no studies2023-01-01T00:00:00Z2023 Feb2025-04-26T10:18:01.365Z2025-04-06T13:19:29.154ZS-EPMC99712603684949110.1038/s41598-023-30164-3