biostudies-literatureMonsour CGNational Science Foundation of Sri LankaNational Institute of General Medical SciencesNIGMS NIH HHSNational Science Foundation672-679https://www.ebi.ac.uk/biostudies/studies/S-EPMC9971345biostudies-literatureUnknown99(2)We investigated the singlet oxygen quenching ability of several derivatives of trans-resveratrol which have been reported to have significant antioxidant ability, including photoprotective activity. We measured the total rate constants of singlet oxygen removal (k_T ) by the methylated resveratrol derivative 1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]benzene, and the partially methylated resveratrol derivatives 4-((E)-2-(3,5-dimethoxyphenyl)ethenyl)phenol (pterostilbene), 5-[(E)-2-(4-methoxyphenyl)ethenyl]benzene-1,3-diol and (2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one (dihydromyricetin). A protic solvent system results in higher k_T values, except for the completely methylated derivative. We also investigated the ability of trans-rPhotochemistry and photobiologySinglet Oxygen Quenching by Resveratrol Derivatives.PMC9971345R25GM061331DRM‐1547723R25 GM061331T34 GM08228DRM-1547723T34 GM008228Lakshmanan NSelke MTafolla-Aguirre BJSabio RBTadle ACYoon JHMonsour CGfalseSinglet Oxygen Quenching by Resveratrol Derivatives.We investigated the singlet oxygen quenching ability of several derivatives of trans-resveratrol which have been reported to have significant antioxidant ability, including photoprotective activity. We measured the total rate constants of singlet oxygen removal (k_T ) by the methylated resveratrol derivative 1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]benzene, and the partially methylated resveratrol derivatives 4-((E)-2-(3,5-dimethoxyphenyl)ethenyl)phenol (pterostilbene), 5-[(E)-2-(4-methoxyphenyl)ethenyl]benzene-1,3-diol and (2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one (dihydromyricetin). A protic solvent system results in higher k_T values, except for the completely methylated derivative. We also investigated the ability of trans-r2023-01-01T00:00:00Z2023 Mar2025-04-03T23:49:43.964Z2025-04-03T23:49:43.964ZS-EPMC99713453603134310.1111/php.13704