{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["MalariaGEN"],"funding":["World Health Organization","NCATS NIH HHS","NIAID NIH HHS","Medical Research Council","NHGRI NIH HHS"],"pagination":["22"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9971654"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8"],"pubmed_abstract":["We describe the MalariaGEN Pf7 data resource, the seventh release of <i>Plasmodium falciparum</i> genome variation data from the MalariaGEN network.  It comprises over 20,000 samples from 82 partner studies in 33 countries, including several malaria endemic regions that were previously underrepresented.  For the first time we include dried blood spot samples that were sequenced after selective whole genome amplification, necessitating new methods to genotype copy number variations.  We identify a large number of newly emerging <i>crt</i> mutations in parts of Southeast Asia, and show examples of heterogeneities in patterns of drug resistance within Africa and within the Indian subcontinent.  We describe the profile of variations in the C-terminal of the <i>csp</i> gene and relate this to t"],"journal":["Wellcome open research"],"pubmed_title":["Pf7: an open dataset of <i>Plasmodium falciparum</i> genome variation in 20,000 worldwide samples."],"pmcid":["PMC9971654"],"funding_grant_id":["001","MR/M006212/1","UL1 TR001863","R01 AI048071","U41 HG006941"],"pubmed_authors":["Duffy P","Konate A","Amenga-Etego L","Enosse SMM","Thu AM","Keatley J","Ruano-Rubio V","Apinjoh T","Mobegi V","Bertin GI","Claessens A","Arnaldo P","Noedl H","Fairhurst RM","Miotto O","Acheampong DO","Conway DJ","Price RN","Craig A","Bull PC","Branch O","Nguyen Van H","Ntui VN","Phyo AP","Peshu N","Djimde A","Oyibo WA","D'Alessandro U","Abdel Hamid MM","Htut Y","Mueller I","Forbes M","Fleharty M","Kyle D","Marsh K","Ishengoma D","Diakite M","Toure M","Johnson KJ","Maiga-Ascofare O","Talman A","Barry A","Day N","Dhorda M","Nguyen Thi Kim T","Lawniczak M","Chookajorn T","Ahouidi A","Ngo Duc T","Gamboa D","Ansah PO","Omedo I","Amaratunga C","Drakeley C","Ringwald P","Jackson SA","Hussein M","Bouyou-Akotet M","Ochola-Oyier LI","Sissoko MS","Rovira-Vallbona E","Golassa L","Imwong M","Lee SK","Montgomery J","Oyebola K","Jeans J","Kamaliddin C","Hott A","Lemnge M","Oduro A","Hernandez-Koutoucheva A","Hill CA","Almagro-Garcia J","Quang HH","Konate DS","Vinetz J","Kochakarn T","Dama S","Pearson R","Cheah H","Hien TT","Egwang TG","Dondorp A","Mita T","Rosanas-Urgell A","Baraka V","Fukuda M","Mayxay M","Healy SA","Kyaw MP","Bejon P","Fanello CA","Tshefu A","Amambua-Ngwa A","Mandara CI","Ruiz L","Saunders D","Wendler J","Doumbia S","Faiz A","Nzila A","Ashley E","Newton PN","Aninagyei E","Ouedraogo JB","Dolecek C","Ghansah A","Su XZ","Chindavongsa K","van der Pluijm RW","Murie K","Nosten F","Siba P","Verra F","Yavo W","Plowe CV","Kamau E","Abdelraheem MH","Bousema T","Echeverry DF","Kwiatkowski DP","Lim P","Andagalu B","Borrmann S","Takala-Harrison S","Randrianarivelojosia M","Mohamed AO","Thathy V","Anderson T","Tavul L","Mokuolu OA","Courtier E","Auburn S","Boni MF","Loua KM","Sutherland C","Kone A","Ba H","Goncalves S","Hendry JA","Aniebo I","Marfurt J","Maude RJ","Nguyen TN","Simpson VJ","Chotivanich K","Rayner JC","Onyamboko MA","Erko B","Drury E","Harrison GLA","Smith C","Nguyen T","Ocholla H","Awandare GA","Jacob CG","Ali M","Andrianaranjaka V","Lon C","Whitton G","Shayo A","Thanh NV","Noviyanti R","MalariaGEN","Hombhanje F","Morang'a CM","Wellems TE","Denis B","Corredor V","Pukrittayakamee S","Ansah F","White NJ"],"additional_accession":[]},"is_claimable":false,"name":"Pf7: an open dataset of <i>Plasmodium falciparum</i> genome variation in 20,000 worldwide samples.","description":"We describe the MalariaGEN Pf7 data resource, the seventh release of <i>Plasmodium falciparum</i> genome variation data from the MalariaGEN network.  It comprises over 20,000 samples from 82 partner studies in 33 countries, including several malaria endemic regions that were previously underrepresented.  For the first time we include dried blood spot samples that were sequenced after selective whole genome amplification, necessitating new methods to genotype copy number variations.  We identify a large number of newly emerging <i>crt</i> mutations in parts of Southeast Asia, and show examples of heterogeneities in patterns of drug resistance within Africa and within the Indian subcontinent.  We describe the profile of variations in the C-terminal of the <i>csp</i> gene and relate this to t","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-19T02:44:30.347Z","creation":"2024-11-09T06:04:37.406Z"},"accession":"S-EPMC9971654","cross_references":{"pubmed":["36864926"],"doi":["10.12688/wellcomeopenres.18681.1"]}}